Measuring the effects of pesticides on occupationally exposed humans with the comet assay

被引：19

作者：

Piperalkis, S. M.

Kontogianni, K.

Siffel, C.

Piperalkis, M. M.

机构：

[1] Univ Thessaly, Biol Unit, Dept Presch Educ, Volos 38221, Greece

[2] Natl Ctr Sci Res Demokritos, DNA Repair Lab, Inst Biol, Athens 15310, Greece

[3] B Johan Natl Ctr Epidemiol, Dept Human Genet & Teratol, Budapest, Hungary

[4] Univ Sheffield, Dept Chem, Sheffield S10 2TN, S Yorkshire, England

来源：

ENVIRONMENTAL TOXICOLOGY | 2006年 / 21卷 / 04期

关键词：

comet assay; human lymphocytes; DNA damage; DNA repair; pesticides;

D O I：

10.1002/tox.20191

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

In this study we examine the effects of a mixture of pesticides on occupationally exposed agricultural workers. The study was performed on 149 people, 84 agricultural workers and 65 healthy men from the same area, who served as the control group. The exposed group was divided into a subgroup with 6:5 individuals moderately exposed (39 men and 26 women) and a highly exposed subgroup consisted of 19 men. The statistical analysis of the comet assay results showed that there were no significant differences in basal DNA damage between pesticide-exposed workers and the control group nor between moderately and highly exposed ones. In addition, exposure of peripheral blood lymphocytes to hydrogen peroxide or gamma-irradiation led to a similar degree of DNA damage and subsequent repair for all the studied populations. (c) 2006 Wiley Pefiodicals, Inc.

引用

页码：355 / 359

页数：5

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