Synthesis and reactivity of 4"-phenylsulfinimine-avermectin B1 and 4′-phenylsulfinimine-avermectin B1 monosaccharide derivative

被引：13

作者：

Lamy, Emmanuel ^{[1
]}

Luethi, Patrick ^{[1
]}

Paturel, Clotilde ^{[1
]}

Winkler, Tammo ^{[1
]}

Jung, Pierre M. J. ^{[1
]}

机构：

[1] Syngenta Crop Protect AG, CH-4002 Basel, Switzerland

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 32期

关键词：

D O I：

10.1016/j.tetlet.2006.06.019

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short, efficient synthesis of 4 ''-(R or S) 4 ''-deoxy-4 ''-amino4 ''-C substituted avermectin B-1 and 4'-(R or S)-4'-deoxy-4'amino-4'-C substituted avermectin B-1 monosaccharide 3 and 4 has been developed through the nucleophilic addition of an organometallic reagent to an intermediate phenylsulfinimide 7. These new derivatives of avermectin B-1 exhibited potent, broad spectrum insecticidal activity. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5657 / 5660

页数：4

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