The human drug metabolizing cytochromes P450

被引：168
|
作者：
Wrighton, SA
VandenBranden, M
Ring, BJ
机构：
[1] Department of Drug Disposition, Eli Lilly and Company, Lilly Corporate Center, Indianapolis
来源：
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS | 1996年 / 24卷 / 05期
关键词：
cytochrome P450; drug metabolism; hepatic; human; in vitro models;
D O I：
10.1007/BF02353474
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The superfamily of heme-thiolate proteins known as the cytochromes P450 if responsible for the oxidative metabolism of the majority of drugs. Thus, the phenotypes of individuals with respect to their levels of catalytically active cytochromes P450 determines to a large part the substantial interindividual variation observed in the metabolic clearance of drugs. Over the past IO years IS different human cytochromes P450 involved in drug metabolism have been isolated and characterized to varying degrees. This brief review discusses the characterization of these cytochromes P450 and how this knowledge has been used by the pharmaceutical industry to aid in the development of new drugs.
引用
收藏
页码：461 / 473
页数：13
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