Clean and one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thione derivatives using maleic acid as an efficient and environmentally benign natural di-functional Bronsted acid catalyst under solvent-free conditions

被引：0
|
作者：
Maghsoodlou, Malek Taher [1 ]
Heydari, Reza [1 ]
Lashkari, Mojtaba [2 ]
Mohamadpour, Farzaneh [1 ]
机构：
[1] Univ Sistan & Baluchestan, Fac Sci, Dept Chem, POB 98135-674, Zahedan, Iran
[2] Velayat Univ, Fac Sci, Iranshahr, Iran
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2017年 / 56卷 / 02期
关键词：
Maleic acid; efficient catalyst; 3,4-dihydropyrimidinone/thione; Biginelli reaction; solvent-free conditions; ecofriendly synthesis; MULTICOMPONENT SYNTHESIS; BIGINELLI REACTION; 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES; TETRAFLUOROBORATE; PROTOCOL; MILD;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthesis of Biginelli-type compounds using maleic acid as an economical di-functional Bronsted acid catalyst in a one-pot, three-component reaction of beta-ketoesters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye derivatives) and urea or thiourea is reported. The present methodology is an environmental friendly approach to access 3,4-dihydropyrimiclin-2-(1H)-ones/tiones derivatives. It offers several merits such as good yields, short reaction times, efficient, eco-friendly, solvent-free conditions, materials available, and simple operational procedure with no column chromatographic separation. The products have been characterized by melting points and H-1 NMR spectroscopy.
引用
收藏
页码：160 / 164
页数：5
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