RBM10 regulates alternative splicing

被引：58

作者：

Inoue, Akira ^{[1
,2
]}

Yamamoto, Naoki ^{[3
]}

Kimura, Masatsugu ^{[4
]}

Nishio, Koji ^{[5
]}

Yamane, Hideo ^{[2
]}

Nakajima, Koichi ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Med, Dept Immunol, Osaka 5458585, Japan

[2] Osaka City Univ, Grad Sch Med, Dept Otolaryngol, Osaka 5458585, Japan

[3] Tokyo Med & Dent Univ, Grad Sch, Dept Psychiat & Behav Sci, Tokyo, Japan

[4] Osaka City Univ, Grad Sch Med, Dept Radioisotope Ctr, Osaka 5458585, Japan

[5] Nagoya Univ, Grad Sch Med, Dept Anat & Cell Biol, Nagoya, Aichi 4648601, Japan

来源：

FEBS LETTERS | 2014年 / 588卷 / 06期

关键词：

S1-1; RBM10; RBM5; Alternative splicing; Fas; Bcl-x; SINGLE-STRANDED RNA; LUNG ADENOCARCINOMA; MOLECULAR-CLONING; TUMOR-SUPPRESSOR; FAS MOLECULE; ZINC FINGERS; CELL-DEATH; BCL-X; PROTEIN; GENE;

D O I：

10.1016/j.febslet.2014.01.052

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RBM10, originally called S1-1, is a nuclear RNA-binding protein with domains characteristic of RNA processing proteins. It has been reported that RBM10 constitutes spliceosome complexes and that RBM5, a close homologue of RBM10, regulates alternative splicing of apoptosis-related genes, Fas and cFLIP. In this study, we examined whether RBM10 has a regulatory function in splicing similar to RBM5, and determined that it indeed regulates alternative splicing of Fas and Bcl-x genes. RBM10 promotes exon skipping of Fas pre-mRNA as well as selection of an internal 5'-splice site in Bcl-x pre-mRNA. We propose a consensus RBM10-binding sequence at 5'-splice sites of target exons and a mechanistic model of RBM10 action in the alternative splicing. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：942 / 947

页数：6

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