One-pot Copper Nanoparticle-catalyzed Synthesis of Imidazo[1,2-a]pyridines Under Solvent-free Conditions

被引：14

作者：

Zong Chenglong ^{[1
]}

Zeng Runsheng ^{[1
]}

Zou Jianping ^{[1
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2014年 / 30卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Copper nanoparticle; Three-component reaction; Solvent-free condition; 2-Aminopyridine; Aldehyde; Alkyne; 3-COMPONENT COUPLING REACTION; ANTIULCER AGENTS; GREEN SYNTHESIS; 2-AMINOPYRIDINES; INHIBITORS; ALDEHYDES; ANALOGS; DESIGN; ALKYNE;

D O I：

10.1007/s40242-014-3520-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A direct and efficient approach to synthesize imidazo[1,2-a]pyridines through three-component one-pot reaction of 2-aminopyridine, aldehyde and terminal alkyne catalyzed by Cu-nanoparticles under solvent-free conditions has been developed. This method provides a rapid access to substituted imidazo[1,2-a]pyridines with good yields(up to 85%).

引用

页码：632 / 638

页数：7

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