The Evaluation of Hydroxyethyl Starch (6% HES 130/0.4) Solution's Potential Preventive Effects on Coagulation Status in Women with Gynecologic Malignancies Using Rotation Thromboelastography

被引：5

作者：

Akay, Meltem Olga ^{[1
]}

Bilir, Ayten ^{[2
]}

Oge, Tufan ^{[3
]}

Kus, Gokhan ^{[1
]}

Mutlu, Fezan Sahin ^{[4
]}

机构：

[1] Eskisehir Osmangazi Univ, Fac Med, Dept Hematol, Eskisehir, Turkey

[2] Eskisehir Osmangazi Univ, Fac Med, Dept Anesthesiol & Reanimat, Eskisehir, Turkey

[3] Eskisehir Osmangazi Univ, Fac Med, Dept Obstet & Gynecol, Eskisehir, Turkey

[4] Eskisehir Osmangazi Univ, Fac Med, Dept Biostat, Eskisehir, Turkey

来源：

TURKISH JOURNAL OF HEMATOLOGY | 2014年 / 31卷 / 03期

关键词：

Blood coagulation; Colloids; Genital neoplasms; Thromboelastography; VENOUS THROMBOEMBOLISM; HEMOSTASIS; HEMODILUTION; CANCER;

D O I：

10.4274/tjh.2013.0003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: The aim of this study was to determine the effects of in vitro hemodilution with 6% hydroxyethyl starch (HES) 130/0.4 solution on the coagulation status of women with gynecologic malignancies by using rotation thromboelastogram (ROTEM (R)). Materials and Methods: Twenty-two patients with gynecological tumors scheduled for anesthesia were enrolled. Blood samples were diluted by 20% with 6% HES (130/0.4) solution. Results: In the INTEM assay, clotting time (CT) (p<0.01) and clot formation time (CFT) (p<0.001) were significantly increased and maximum maximum clot formation (MCF) (p< 0.001) was significantly decreased in HES hemodilution compared with the undiluted control samples. In the EXTEM assay, there was a similar significant increase in increase in CFT (p<0.01) and a decrease in maximum a decrease in MCF (p<0.01) in HES hemodilution when compared with control samples. Conclusion: HES 130/0.4 solution causes significant hypocoagulable changes in the thromboelastographic profile of gynecologic cancer patients in vitro.

引用

页码：261 / 265

页数：5

共 5 条

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