The effects of in vitro hemodilution with 6% hydroxyethyl starch (HES) (130/0.4) solution on thrombelastograph analysis in patients undergoing liver transplantation

被引：8
|
作者：
Bang, Si Ra [2 ]
Kim, Yoon Hee [1 ]
Kim, Gaab Soo [3 ]
机构：
[1] Chungnam Natl Univ Hosp, Dept Anesthesiol & Pain Med, Taejon 301721, South Korea
[2] Inje Univ, Haeundae Paik Hosp, Dept Anesthesiol & Pain Med, Pusan, South Korea
[3] Sungkyunkwan Univ, Samsung Med Ctr, Dept Anesthesiol & Pain Med, Seoul, South Korea
来源：
CLINICAL TRANSPLANTATION | 2011年 / 25卷 / 03期
关键词：
6% HES 130; 0; 4 (hydroxyethyl starch) solution; end-stage liver disease; hemodilution; liver transplantation; thrombelastograph; COAGULATION; SURGERY; SALINE; DISEASE; COAGULOPATHY; ACTIVATION; COLLOIDS; GELATIN;
D O I：
10.1111/j.1399-0012.2010.01294.x
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Introduction: The aim of this study was to determine the effects of in vitro hemodilution with 6% HES (130/0.4) solution on thrombelastograph (R) (TEG) parameters in whole blood samples from patients with end-stage liver disease (ESLD). Methods: Enrollment consisted of 95 patients with ESLD undergoing liver transplantation. Blood was diluted by 11%, 22%, and 33% with 6% HES (130/0.4) solution. Normal saline was used as a control diluent. Results: When blood was diluted by 33% with normal saline, only the reaction time (r) was increased (p < 0.0001) compared to the baseline value. When blood was diluted with 6% HES (130/0.4), 11% dilution decreased maximum amplitude (MA) (p = 0.003) compared to baseline. At 33% dilution, the r (p < 0.0001, vs. baseline) and K (p < 0.0001, vs. baseline; p < 0.0001, vs. normal saline) increased, and the MA, alpha angle, and coagulation index (p < 0.0001, vs. baseline; p < 0.0001, vs. normal saline) decreased. Conclusion: Hemodilution with 6% HES (130/0.4) solution results in TEG abnormalities even with 11% hemodilution, in whole blood samples of patients with ESLD undergoing liver transplantation.
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页码：450 / 456
页数：7
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