TBAF-Assisted Copper-Catalyzed N-Arylation and Benzylation of Benzazoles with Aryl and Benzyl Halides under the Ligand/Base/Solvent-Free Conditions

被引：46

作者：

Lee, Hyung-Geun ^{[1
]}

Won, Ju-Eun ^{[1
]}

Kim, Min-Jung ^{[1
]}

Park, Song-Eun ^{[1
]}

Jung, Kwang-Ju ^{[1
]}

Kim, Bo Ram ^{[1
]}

Lee, Sang-Gyeong ^{[1
]}

Yoon, Yong-Jin ^{[1
]}

机构：

[1] Gyeongsang Natl Univ, Dept Chem & Environm Biotechnol, Natl Core Res Ctr, Res Inst Nat Sci,Grad Sch Mol Mat & Nanochem, Jinju 660701, South Korea

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 15期

关键词：

PHASE-TRANSFER CATALYSIS; HETEROARYL HALIDES; ULLMANN SYNTHESIS; EFFICIENT; IMIDAZOLES; INHIBITORS; BENZOTRIAZOLE; HETEROCYCLES; RECEPTOR; SOLVENT;

D O I：

10.1021/jo900752z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

TBAF-assisted N-arylation and benzylation of benzazoles such as I H-benzimidazole, 1H-indole, and 1H-benzotriazole with aryl and benzyl halides have been demonstrated tinder the ligand/base/solvent-free conditions. In the presence of CuBr2 and TBAF (n-Bu4NF), the azoles underwent N-arylation and benzylation with aryl and benzyl halides smoothly in moderate to good yields. It is noteworthy that the reaction is conducted under the ligand/base/solvent-free conditions.

引用

页码：5675 / 5678

页数：4

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