Cellular mechanisms regulating human melanogenesis

被引：309
|
作者：
Park, H. Y. [1 ]
Kosmadaki, M. [1 ]
Yaar, M. [1 ]
Gilchrest, B. A. [1 ]
机构：
[1] Boston Univ, Sch Med, Dept Dermatol, Boston, MA 02118 USA
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2009年 / 66卷 / 09期
关键词：
Melanogenesis; melanosomes; UV; DNA damages; and melanocytes; NERVE GROWTH-FACTOR; MELANOCYTE-STIMULATING-HORMONE; CULTURED HUMAN MELANOCYTES; PROTEIN-KINASE-C; NECROSIS-FACTOR-ALPHA; TYROSINASE-RELATED PROTEIN; TRANSCRIPTION FACTOR MITF; NITRIC-OXIDE SYNTHASE; DNA-DAMAGE RESPONSES; HUMAN-SKIN;
D O I：
10.1007/s00018-009-8703-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The major differentiated function of melanocytes is the synthesis of melanin, a pigmented heteropolymer that is synthesized in specialized cellular organelles termed melanosomes. Mature melanosomes are transferred to neighboring keratinocytes and are arranged in a supranuclear cap, protecting the DNA against incident ultraviolet light (UV) irradiation. The synthesis and distribution of melanin in the epidermis involves several steps: transcription of melanogenic proteins, melanosome biogenesis, sorting of melanogenic proteins into the melanosomes, transport of melanosomes to the tips of melanocyte dendrites and finally transfer into keratinocytes. These events are tightly regulated by a variety of paracrine and autocrine factors in response to endogenous and exogenous stimuli, principally UV irradiation.
引用
收藏
页码：1493 / 1506
页数：14
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