Two Mixed-Ligand Co(II) Coordination Polymers: Clinical Nursing Application Values in the Treatment of Pancreatitis

In the current study, via using the mixed-ligand synthesis approach, two new Co(II)-containing coordination polymers (CPs) with the chemical compositions of {[Co-3(cpboda)(2)(phen)(3)(H2O)(2)]center dot 4H(2)O}(n) (1, Phen = 1,10-phenanthroline) and [Co(Hcpboda)(2,2-bipy)(H2O)](n) (2, 2,2-bipy = 2,2-bipyridine) have been successfully prepared by reaction of the corresponding metal salts with the flexible carboxylic ligand 3,3'-((5-carboxy-1,3-phenylene)bis(oxy))dibenzoic acid (H(3)cpboda) in the presence of different N-donor co-ligands. For the treatment of pancreatitis, the biological activity of the new compounds was evaluated and the mechanism was explored as well. Firstly, the content of inflammatory cytokines released into the peritoneal lavage fluid was measured with ELISA assay. In addition to this, the real time RT-PCR was performed and the activation of the NF.B signaling pathway was measured.