Stampidine is a potent inhibitor of zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations

被引：47
|
作者：
Uckun, FM
Pendergrass, S
Venkatachalam, TK
Qazi, S
Richman, D
机构：
[1] Parker Hughes Inst, Drug Discovery Program, Dept Virol, St Paul, MN 55113 USA
[2] Parker Hughes Inst, Drug Discovery Program, Dept Bioinformat, St Paul, MN 55113 USA
[3] Parker Hughes Inst, Drug Discovery Program, Dept Immunol, St Paul, MN 55113 USA
[4] Parker Hughes Inst, Drug Discovery Program, Dept Chem, St Paul, MN 55113 USA
[5] Parker Hughes Ctr Clin Immunol, Roseville, MN USA
[6] Univ Calif San Diego, Virol Sect, La Jolla, CA 92093 USA
[7] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA
[8] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
[9] VA San Diego Healthcare Syst, La Jolla, CA USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 11期
关键词：
D O I：
10.1128/AAC.46.11.3613-3616.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We report the antiretroviral activity of stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate) (stampidine [STAMP]), a novel aryl phosphate derivative of stavudine, against primary clinical human immunodeficiency virus type 1 (HIV-1) isolates. STAMP inhibited each one of nine clinical HIV-1 isolates of non-B envelope subtype and 20 genotypically and phenotypically nucleoside analog reverse transcriptase inhibitor-resistant HIV-1 isolates at subnanomolar to low-nanomolar concentrations.
引用
收藏
页码：3613 / 3616
页数：4
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