PKM2: a crucial neuroprotective target against oxidative stress

被引:5
|
作者
Zhou, Qionglin [1 ]
Tang, Mingzhu [2 ]
He, Lu [3 ]
Chen, Shuiping [1 ]
机构
[1] Southern Med Univ, Shaoguan Hosp, Peoples Hosp Shaoguan 1, Dept Pharm, Shaoguan 512000, Peoples R China
[2] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou Regenerat Med & Hlth Guangdong Lab, Guangzhou 510530, Peoples R China
[3] Univ South China, Dept Neurosurg, Affiliated Hosp 1, Hengyang 421001, Peoples R China
基金
中国国家自然科学基金;
关键词
PYRUVATE-KINASE; METABOLISM; NEURONS; M2;
D O I
10.1093/abbs/gmaa121
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:1432 / 1434
页数:3
相关论文
共 50 条
  • [11] PKM2 Is a Potential Diagnostic and Therapeutic Target for Retinitis Pigmentosa
    Zhu, Peiwen
    Yang, Qian
    Li, Gang
    Chang, Qing
    DISEASE MARKERS, 2021, 2021
  • [12] PKM2 functions as a potential oncogene and is a crucial target of miR-148a and miR-326 in thyroid tumorigenesis
    Yu, Gang
    Sung, Weili
    Shen, Yong
    Hu, Yongquan
    Liu, Henchao
    Li, Weipeng
    Wang, Yong
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2018, 10 (06): : 1793 - 1801
  • [13] PKM2 as a protein kinase
    Rachel David
    Nature Reviews Molecular Cell Biology, 2012, 13 (3) : 139 - 139
  • [14] 3,3′,5-triiodothyroxine inhibits apoptosis and oxidative stress by the PKM2/PKM1 ratio during oxygen-glucose deprivation/reperfusion AC16 and HCM-a cells T3 inhibits apoptosis and oxidative stress by PKM2/PKM1 ratio
    Li, Qi
    Qi, Xin
    Jia, Wenjun
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 475 (01) : 51 - 56
  • [15] PKM2 in carcinogenesis and oncotherapy
    He, Xia
    Du, Suya
    Lei, Tiantian
    Li, Xiang
    Liu, Yilong
    Wang, Hailian
    Tong, Rongsheng
    Wang, Yi
    ONCOTARGET, 2017, 8 (66) : 110656 - 110670
  • [16] PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma
    Feng, Jiao
    Wu, Liwei
    Ji, Jie
    Chen, Kan
    Yu, Qiang
    Zhang, Jie
    Chen, Jiaojiao
    Mao, Yuqing
    Wang, Fan
    Dai, Weiqi
    Xu, Ling
    Wu, Jianye
    Guo, Chuanyong
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2019, 38 (1)
  • [17] PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma
    Jiao Feng
    Liwei Wu
    Jie Ji
    Kan Chen
    Qiang Yu
    Jie Zhang
    Jiaojiao Chen
    Yuqing Mao
    Fan Wang
    Weiqi Dai
    Ling Xu
    Jianye Wu
    Chuanyong Guo
    Journal of Experimental & Clinical Cancer Research, 38
  • [18] PKM2 functions as a histone kinase
    Lu, Zhimin
    CELL CYCLE, 2012, 11 (22) : 4101 - 4102
  • [19] The Role of PKM2 in Diabetic Microangiopathy
    Tu, Chao
    Wang, Liangzhi
    Wei, Lan
    DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY, 2022, 15 : 1405 - 1412
  • [20] Comprehensive analyses of the cysteine thiol oxidation of PKM2 reveal the effects of multiple oxidation on cellular oxidative stress response
    Irokawa, Hayato
    Numasaki, Satoshi
    Kato, Shin
    Iwai, Kenta
    Inose-Maruyama, Atsushi
    Ohdate, Takumi
    Hwang, Gi-Wook
    Toyama, Takashi
    Watanabe, Toshihiko
    Kuge, Shusuke
    BIOCHEMICAL JOURNAL, 2021, 478 (07) : 1453 - 1470