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Heinrich Heine Univ, Ctr Child & Adolescent Hlth, Dept Pediat Oncol Hematol & Clin Immunol, Fac Med, D-40225 Dusseldorf, Germany Heinrich Heine Univ, Ctr Child & Adolescent Hlth, Dept Pediat Oncol Hematol & Clin Immunol, Fac Med, D-40225 Dusseldorf, Germany