Mixed pleomorphic lobular and apocrine carcinoma of the breast: A case report suggesting pathogenesis

被引：2

作者：

Ishii, Akiko ^{[1
,2
]}

Oishi, Takuma ^{[1
]}

Kakuda, Yuko ^{[1
]}

Yasui, Haruna ^{[1
]}

Kawata, Takuya ^{[1
]}

Muramatsu, Koji ^{[1
]}

Takahashi, Kaoru ^{[3
]}

Sugino, Takashi ^{[1
]}

机构：

[1] Shizuoka Canc Ctr Hosp, Div Pathol, Shimonagakubo 1007, Nagaizumi, Shizuoka 4118777, Japan

[2] Univ Ryukyus, Grad Sch Med, Dept Pathol & Oncol, Nishihara, Okinawa, Japan

[3] Shizuoka Canc Ctr Hosp, Div Breast Surg, Nagaizumi, Shizuoka, Japan

来源：

PATHOLOGY INTERNATIONAL | 2019年 / 69卷 / 05期

关键词：

apocrine carcinoma; breast carcinoma; E-cadherin; mixed carcinoma; pleomorphic lobular carcinoma; DUCTAL CARCINOMA; FEATURES; EXPRESSION; OUTCOMES; CANCER;

D O I：

10.1111/pin.12781

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Pleomorphic lobular carcinoma (PLC) of the breast is a variant of lobular carcinoma, characterized by loss of E-cadherin expression and high-grade morphologies. Whether the pathogenesis of PLC is in the ductal or the lobular lineage has been discussed. In this report, a case of PLC combined with apocrine carcinoma is presented. Histologically, the tumor showed two distinct carcinoma components: one was a typical apocrine carcinoma, and the other was a pleomorphic invasive lobular carcinoma. The former showed complete membranous expression of E-cadherin, whereas the latter aberrantly expressed it not on the cell membrane, but in the cytoplasm. Both components were triple-negative and strongly positive for GCDFP-15, suggesting apocrine differentiation. The intraductal component showed only a feature of apocrine ductal carcinoma in situ. This case suggests that apocrine carcinoma could be an origin of PLC.

引用

页码：288 / 293

页数：6

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