Mixed pleomorphic lobular and apocrine carcinoma of the breast: A case report suggesting pathogenesis

被引：2
|
作者：
Ishii, Akiko [1 ,2 ]
Oishi, Takuma [1 ]
Kakuda, Yuko [1 ]
Yasui, Haruna [1 ]
Kawata, Takuya [1 ]
Muramatsu, Koji [1 ]
Takahashi, Kaoru [3 ]
Sugino, Takashi [1 ]
机构：
[1] Shizuoka Canc Ctr Hosp, Div Pathol, Shimonagakubo 1007, Nagaizumi, Shizuoka 4118777, Japan
[2] Univ Ryukyus, Grad Sch Med, Dept Pathol & Oncol, Nishihara, Okinawa, Japan
[3] Shizuoka Canc Ctr Hosp, Div Breast Surg, Nagaizumi, Shizuoka, Japan
来源：
PATHOLOGY INTERNATIONAL | 2019年 / 69卷 / 05期
关键词：
apocrine carcinoma; breast carcinoma; E-cadherin; mixed carcinoma; pleomorphic lobular carcinoma; DUCTAL CARCINOMA; FEATURES; EXPRESSION; OUTCOMES; CANCER;
D O I：
10.1111/pin.12781
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Pleomorphic lobular carcinoma (PLC) of the breast is a variant of lobular carcinoma, characterized by loss of E-cadherin expression and high-grade morphologies. Whether the pathogenesis of PLC is in the ductal or the lobular lineage has been discussed. In this report, a case of PLC combined with apocrine carcinoma is presented. Histologically, the tumor showed two distinct carcinoma components: one was a typical apocrine carcinoma, and the other was a pleomorphic invasive lobular carcinoma. The former showed complete membranous expression of E-cadherin, whereas the latter aberrantly expressed it not on the cell membrane, but in the cytoplasm. Both components were triple-negative and strongly positive for GCDFP-15, suggesting apocrine differentiation. The intraductal component showed only a feature of apocrine ductal carcinoma in situ. This case suggests that apocrine carcinoma could be an origin of PLC.
引用
收藏
页码：288 / 293
页数：6
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