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Tianjin Med Univ, Canc Inst & Hosp, Key Lab Breast Canc Prevent & Therapy, Dept Breast Oncol,Canc Res Key Lab,Educ Minist, Tianjin 300060, Peoples R China Tianjin Med Univ, Canc Inst & Hosp, Key Lab Breast Canc Prevent & Therapy, Dept Breast Oncol,Canc Res Key Lab,Educ Minist, Tianjin 300060, Peoples R China