Edaravone for acute stroke: Meta-analyses of data from randomized controlled trials

被引：33
|
作者：
Yang, Jie [1 ,2 ]
Cui, Xiaoyang [1 ]
Li, Jie [1 ,3 ]
Zhang, Canfei [1 ]
Zhang, Jing [1 ]
Liu, Ming [1 ]
机构：
[1] Sichuan Univ, Dept Neurol, West China Hosp, 37 Guo Xue Xiang, Chengdu 610041, Peoples R China
[2] Nanjing Med Univ, Nanjing Hosp 1, Dept Neurol, Nanjing, Jiangsu, Peoples R China
[3] Peoples Hosp Deyang City, Dept Neurol, Deyang, Peoples R China
来源：
DEVELOPMENTAL NEUROREHABILITATION | 2015年 / 18卷 / 05期
关键词：
Free radical scavenger; acute stroke treatment; meta-analysis; FREE-RADICAL SCAVENGER; CEREBRAL INFARCTION; ISCHEMIC-STROKE; DOUBLE-BLIND; PREVENTION;
D O I：
10.3109/17518423.2013.830153
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Aims: To assess the effectiveness of edaravone for acute stroke including ischemic stroke and intracerebral hemorrhage (ICH).Methods: We identified randomized controlled trials with comprehensive searches and performed systematic reviews according to the Cochrane methods of systematical reviews.Results: Edaravone can reduce the rate of death or long-term disability significantly for acute ischemic stroke (AIS) (RR=0.65; 95%CI, 0.48 to 0.89, p=0.007). However, sensitivity analysis yielded a different result. Edaravone can also improve the short-term neurological impairment of AIS (MD=7.09; 95%CI, 5.12 to 9.05, p<0.00001), and ICH (MD=-4.32; 95%CI, -5.35 to -3.29, p<0.00001).Conclusions: Edaravone is beneficial in improving neurological impairment resulting from AIS and ICH. However, currently there is no enough convincing evidence that edaravone reduces death or long-term disability for AIS and ICH.
引用
收藏
页码：330 / 335
页数：6
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