Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

被引：68

作者：

Ghezzi, Silvia ^{[1
]}

Cooper, Lynsay ^{[2
]}

Rubio, Alicia ^{[1
]}

Pagani, Isabel ^{[1
]}

Capobianchi, Maria Rosaria ^{[3
]}

Ippolito, Giuseppe ^{[3
]}

Pelletier, Julien ^{[2
,4
]}

Meneghetti, Maria Cecilia Z. ^{[5
]}

Lima, Marcelo A. ^{[5
,6
]}

Skidmore, Mark A. ^{[2
,6
]}

Broccoli, Vania ^{[7
]}

Yates, Edwin A. ^{[2
,5
,6
]}

Vicenzi, Elisa ^{[1
]}

机构：

[1] Ist Sci San Raffaele, Via Olgettina, I-20132 Milan, Italy

[2] Keele Univ, Sch Life Sci, Keele ST5 5BG, Staffs, England

[3] Lazzaro Spallanzani Natl Inst Infect Dis, Rome, Italy

[4] Univ Estadual Paulista Julio de Mesquito Filho, Inst Biotecnol, BR-18607440 Botucatu, SP, Brazil

[5] Univ Fed Sao Paulo, Dept Biochem, Rua Tres de Maio, BR-04044020 Sao Paulo, SP, Brazil

[6] Univ Liverpool, Dept Biochem, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England

[7] CNR, CNR, Inst Neurosci, Milan, Italy

来源：

ANTIVIRAL RESEARCH | 2017年 / 140卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

Zika virus (ZIKV); Neural progenitor cells; Heparin; Cell death; HERPES-SIMPLEX-VIRUS; INFLAMMATORY RESPONSE; SEXUAL TRANSMISSION; INFECTION; DERIVATIVES; MECHANISM; SULFATE; ENTRY;

D O I：

10.1016/j.antiviral.2016.12.023

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs). (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：13 / 17

页数：5

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