Gossypol induced apoptosis in the human promyelocytic leukemia cell line HL 60

被引：28
|
作者：
Balci, A [1 ]
Sahin, FI [1 ]
Ekmekci, A [1 ]
机构：
[1] Gazi Univ, Fac Med, Dept Med Biol & Genet, TR-06510 Ankara, Turkey
来源：
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1999年 / 189卷 / 01期
关键词：
apoptosis; gossypol; protein kinase;
D O I：
10.1620/tjem.189.51
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In human promyelocytic leukemia cell line HL60, apoptosis was induced by treatment with gossypol that is an inhibitor of protein kinase C. Gossypol acetic acid mas added to HL 60 cells at 50, 100, 180 and 200 mu M concentrations for six hours. Morphological features of apoptosis as well as internucleosomal DNA fragmentation mere evaluated by light microscope, agarose gel electrophoresis and spectrofluorometric quantitation. Our results indicated that with the effective concentrations of gossypol (50 and 100 mu M), apoptosis was induced in HL 60 cells.
引用
收藏
页码：51 / 57
页数：7
相关论文
共 50 条
  • [41] PHORBOL DIESTER-INDUCED DIFFERENTIATION OF THE HUMAN PROMYELOCYTIC LEUKEMIA-CELL LINE HL-60 - BIOCHEMICAL ASPECTS
    ABITA, JP
    IRCS MEDICAL SCIENCE-BIOCHEMISTRY, 1984, 12 (09): : 775 - 778
  • [42] PERTUSSIS TOXIN INHIBITS DIFFERENTIATION INDUCED BY RETINOIC ACID IN A HUMAN PROMYELOCYTIC LEUKEMIA-CELL LINE HL-60
    HEMMI, H
    NAKAMURA, T
    GOTO, Y
    SUGAMURA, K
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 163 (02) : 797 - 802
  • [43] Mechanism of dibucaine-induced apoptosis in promyelocytic leukemia cells (HL-60)
    Arita, K
    Utsumi, T
    Kato, A
    Kanno, T
    Kobuchi, H
    Inoue, B
    Akiyama, J
    Utsumi, K
    BIOCHEMICAL PHARMACOLOGY, 2000, 60 (07) : 905 - 915
  • [44] Induction of Apoptosis in Human Promyelocytic Leukemia HL60 Cells by Panaxynol and Panaxydol
    Yan, Zhonghong
    Yang, Ruolin
    Jiang, Yi
    Yang, Zhihui
    Yang, Junrui
    Zhao, Qian
    Lu, Yang
    MOLECULES, 2011, 16 (07) : 5561 - 5573
  • [45] Chlorogenic acid induced apoptosis and inhibition of proliferation in human acute promyelocytic leukemia HL-60 cells
    Liu, Ya-Jing
    Zhou, Chang-Yang
    Qiu, Chun-Hong
    Lu, Xiu-Min
    Wang, Yong-Tang
    MOLECULAR MEDICINE REPORTS, 2013, 8 (04) : 1106 - 1110
  • [46] Baicalein induced in vitro apoptosis undergo caspases activity in human promyelocytic leukemia HL-60 cells
    Li, YC
    Tyan, YS
    Kuo, HM
    Chang, WC
    Hsia, TC
    Chung, JG
    FOOD AND CHEMICAL TOXICOLOGY, 2004, 42 (01) : 37 - 43
  • [47] TERMINAL DIFFERENTIATION OF THE HUMAN PROMYELOCYTIC LEUKEMIA-CELL LINE, HL-60, IN THE ABSENCE OF CELL-PROLIFERATION
    FERRERO, D
    TARELLA, C
    GALLO, E
    RUSCETTI, FW
    BREITMAN, TR
    CANCER RESEARCH, 1982, 42 (11) : 4421 - 4426
  • [48] Induction of differentiation and apoptosis in human promyelocytic leukaemia cell line HL60 by ionizing radiation.
    Adomaitiene, DI
    Aleksandraviciene, C
    Savickiene, J
    Breivis, P
    ANNALS OF ONCOLOGY, 2000, 11 : 142 - 142
  • [49] DADS-induced apoptosis through the activation of the MAPK pathway in human leukemia cell line HL-60
    Tan, H
    Su, Q
    Huang, WG
    He, J
    Song, Y
    FEBS JOURNAL, 2005, 272 : 446 - 446
  • [50] Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compounds
    Iwata, K
    Ogata, S
    Okumura, K
    Taguchi, H
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2003, 67 (05) : 1132 - 1135
12345