Biomarkers as outcome predictors in subarachnoid hemorrhage a systematic review

被引:45
|
作者
Hong, Caron M. [1 ]
Tosun, Cigdem [2 ]
Kurland, David B. [2 ]
Gerzanich, Volodymyr [2 ]
Schreibman, David [1 ]
Simard, J. Marc [2 ,3 ,4 ]
机构
[1] Univ Maryland, Sch Med, Dept Anesthesiol, Div Crit Care Med, Baltimore, MD 21230 USA
[2] Univ Maryland, Sch Med, Dept Neurosurg, Baltimore, MD 21230 USA
[3] Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21230 USA
[4] Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21230 USA
关键词
Biomarkers; critical care; markers; outcome; subarachnoid hemorrhage; vasospasm; C-REACTIVE PROTEIN; ENDOTHELIAL-CELL ACTIVATION; DELAYED CEREBRAL-ISCHEMIA; CARDIAC TROPONIN-I; INTERCELLULAR-ADHESION MOLECULE-1; APOLIPOPROTEIN-E POLYMORPHISM; NEURON-SPECIFIC ENOLASE; NECROSIS-FACTOR-ALPHA; EARLY BRAIN-INJURY; CEREBROSPINAL-FLUID;
D O I
10.3109/1354750X.2014.881418
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Context: Subarachnoid hemorrhage (SAH) has a high fatality rate and many suffer from delayed neurological deficits. Biomarkers may aid in the identification of high- risk patients, guide treatment/ management and improve outcome. Objective: The aim of this review was to summarize biomarkers of SAH associated with outcome. Methods: An electronic database query was completed, including an additional review of reference lists to include all potential human studies. Results: A total of 298 articles were identified; 112 were reviewed; 55 studies were included. Conclusion: This review details biomarkers of SAH that correlate with outcome. It provides the basis for research investigating their possible translation into the management of SAH patients.
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页码:95 / 108
页数:14
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