Synthesis of α-alkylidene-γ-butyrolactones via ring-cleavage/recyclization of 2-amino-4,5-dihydro-3-furancarboxamides

被引：1

作者：

Okabe, F ^{[1
]}

Tagawa, Y ^{[1
]}

Yamagata, K ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Jounan Ku, Fukuoka 8140180, Japan

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2004年 / 41卷 / 04期

关键词：

D O I：

10.1002/jhet.5570410405

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reactions of 2-amino-4,5-dihydro-3-furancarboxamides 1a,b with cyanomethylene compounds (such as alkyl cyanoacetates and malononitrile) gave the corresponding ring-opened products 2a-f. Compounds 2a-d reacted with methanesulfonic acid to give the corresponding alpha-alkylidene-gamma-butyrolactones 3a-d. On the other hand, treatment of 2e,f with methanesulfonic acid yielded 3-pyridinecarbonitrile derivatives 4a,b.

引用

页码：505 / 508

页数：4

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