Tertiary amine self-catalyzed intramolecular Csp3-H functionalization with in situ generated allenes for the formation of 3-alkenyl indolines

被引：19

作者：

Zhao, Yulei ^{[1
]}

Xu, Murong ^{[1
]}

Zheng, Zhong ^{[1
]}

Yuan, Yang ^{[1
]}

Li, Yanzhong ^{[1
]}

机构：

[1] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 500 Dongchuan Rd, Shanghai 200241, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 26期

基金：

中国国家自然科学基金;

关键词：

C-H BONDS; ANNULATIONS; CYCLOISOMERIZATION; CYCLIZATION; ACTIVATION; ALLENOATES;

D O I：

10.1039/c7cc00005g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel methodology for the synthesis of 3-alkenyl indolines through the reaction of in situ generated allenes with N-benzylic C-sp3-H has been developed. The reaction was realized by Pd(0) catalyzed allenylation of propargyl carbonate with organoboron and subsequent tertiary amine self-catalyzed C-sp3-H functionalization in a one-pot process. Control reactions suggested that the substrate itself might also serve as a Lewis base for the N-benzylic C-sp3-H functionalization.

引用

页码：3721 / 3724

页数：4