Ebola Virus Replication Stands Out

被引：1
|
作者：
Wang, Wenjie [1 ]
Wu, Chao [1 ]
Amarasinghe, Gaya K. [1 ]
Leung, Daisy W. [1 ,2 ]
机构：
[1] Washington Univ, Dept Pathol & Immunol, Sch Med St Louis, St Louis, MO 63110 USA
[2] Washington Univ, Dept Med, Sch Med St Louis, St Louis, MO 63110 USA
来源：
TRENDS IN MICROBIOLOGY | 2019年 / 27卷 / 07期
关键词：
RNA-SYNTHESIS; INITIATION; MECHANISM;
D O I：
10.1016/j.tim.2019.05.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A recent study by Deflube et al. (Proc. Natl Acad. Sci. U. S. A. 2019; 116: 8535-8543) reported that Ebola virus genomes have variable 3' terminal nucleotides. This finding is a departure from other nonsegmented, negative-strand RNA viruses (NNSVs) that have been studied to date and has broad implications for filoviral replication and innate immune evasion.
引用
收藏
页码：565 / 566
页数：2
相关论文
共 50 条
  • [21] The Ebola virus genomic replication promoter is bipartite and follows the rule of six
    Weik, M
    Enterlein, S
    Schlenz, K
    Mühlberger, E
    JOURNAL OF VIROLOGY, 2005, 79 (16) : 10660 - 10671
  • [22] DNA Topoisomerase 1 Facilitates the Transcription and Replication of the Ebola Virus Genome
    Takahashi, Kei
    Halfmann, Peter
    Oyama, Masaaki
    Kozuka-Hata, Hiroko
    Noda, Takeshi
    Kawaoka, Yoshihiro
    JOURNAL OF VIROLOGY, 2013, 87 (16) : 8862 - 8869
  • [23] The Roles of Ebola Virus Soluble Glycoprotein in Replication, Pathogenesis, and Countermeasure Development
    Zhu, Wenjun
    Banadyga, Logan
    Emeterio, Karla
    Wong, Gary
    Qiu, Xiangguo
    VIRUSES-BASEL, 2019, 11 (11):
  • [24] Analysis of the role of predicted RNA secondary structures in Ebola virus replication
    Crary, SM
    Towner, JS
    Honig, JE
    Shoemaker, TR
    Nichol, ST
    VIROLOGY, 2003, 306 (02) : 210 - 218
  • [25] Active Ebola Virus Replication and Heterogeneous Evolutionary Rates in EVD Survivors
    Whitmer, Shannon L. M.
    Ladner, Jason T.
    Wiley, Michael R.
    Patel, Ketan
    Dudas, Gytis
    Rambaut, Andrew
    Sahr, Foday
    Prieto, Karla
    Shepard, Samuel S.
    Carmody, Ellie
    Knust, Barbara
    Naidoo, Dhamari
    Deen, Gibrilla
    Formenty, Pierre
    Nichol, Stuart T.
    Palacios, Gustavo
    Stroeher, Ute
    CELL REPORTS, 2018, 22 (05): : 1159 - 1168
  • [26] Short report: Lack of virus replication in arthropods after intrathoracic inoculation of Ebola Reston virus
    Turell, MJ
    Bressler, DS
    Rossi, CA
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1996, 55 (01): : 89 - 90
  • [27] Ebola virus replication is regulated by the phosphorylation of viral protein VP35
    Zhu, Lin
    Gao, Ting
    Yang, Weihong
    Liu, Yaoning
    Liu, Xuan
    Hu, Yong
    Jin, Yanwen
    Li, Ping
    Xu, Ke
    Zou, Gang
    Zhao, Lei
    Cao, Ruiyuan
    Zhong, Wu
    Xia, Xianzhu
    Cao, Cheng
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 521 (03) : 687 - 692
  • [28] A high throughput screen identifies benzoquinoline compounds as inhibitors of Ebola virus replication
    Luthra, Priya
    Liang, Jue
    Pietzsch, Colette A.
    Khadka, Sudip
    Edwards, Megan R.
    Wei, Shuguang
    De, Sampriti
    Posner, Bruce
    Bukreyev, Alexander
    Ready, Joseph M.
    Basler, Christopher F.
    ANTIVIRAL RESEARCH, 2018, 150 : 193 - 201
  • [29] The Cytoprotective Enzyme Heme Oxygenase-1 Suppresses Ebola Virus Replication
    Hill-Batorski, Lindsay
    Halfmann, Peter
    Neumann, Gabriele
    Kawaoka, Yoshihiro
    JOURNAL OF VIROLOGY, 2013, 87 (24) : 13795 - 13802
  • [30] Inhibition of heat-shock protein 90 reduces Ebola virus replication
    Smith, Darci R.
    McCarthy, Sarah
    Chrovian, Andrew
    Olinger, Gene
    Stossel, Andrea
    Geisbert, Thomas W.
    Hensley, Lisa E.
    Connor, John H.
    ANTIVIRAL RESEARCH, 2010, 87 (02) : 187 - 194
12345