Fast and Eco-friendly UV Spectrophotometric and HPLC Assay Methods for Estimation of Esmolol in Pharmaceutical Formulation

被引：0
|
作者：
Souza, Thiago V. A. [1 ]
Takano, Diogo E. N. [1 ]
Kassab, Najla M. [2 ]
do Amaral, Marcos S.
Santoro, Maria I. R. M. [1 ]
Singh, Anil K. [1 ]
机构：
[1] Univ Sao Paulo, Dept Pharm, Fac Pharmaceut Sci, BR-05315970 Sao Paulo, SP, Brazil
[2] Univ Fed Mato Grosso do Sul, Ctr Ciencias Biol & Saude, Campo Grande, MS, Brazil
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2015年 / 34卷 / 09期
基金：
巴西圣保罗研究基金会;
关键词：
ecofriendly assay methods; esmolol hydrochloride; high performance liquid chromatography; injectable; UV-VIS spectrophotometry; LIQUID-CHROMATOGRAPHIC ASSAY; ACTING BETA-BLOCKER; HYDROCHLORIDE; METABOLITE;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Esmolol HCL (ESM) is a drug with an ultra-fast and short duration action. Its beta-1 adrenergic receptors blocking capacity is responsible for its therapeutic activity, that rapidly reduces the force and rate of heart contraction. To assure the quality, safety and efficacy of ESM, it is important to develop efficient and accurate analytical methods for its quantitative determination in pharmaceutical dosage forms. A new UV spectrophotometric method and a fast, ecofriendly HPLC method were developed and applied in the analysis of esmolol in pharmaceutical injection. The proposed chromatographic method generates negligible quantities (40 mu L min(-1)) of organic waste material. Moreover, the impact of background pH on protonalion state of esmolol in UV region and correlation with absorption spectra is discussed.
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页码：1743 / 1748
页数：6
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