Quaternary ammonium N,N-dichloroamines as topical, antimicrobial agents

被引：24

作者：

Francavilla, Charles ^{[1
]}

Low, Eddy ^{[1
]}

Nair, Satheesh ^{[1
]}

Kim, Bum ^{[1
]}

Shiau, Timothy P. ^{[1
]}

Debabov, Dmitri ^{[1
]}

Celeri, Chris ^{[1
]}

Alvarez, Nichole ^{[1
]}

Houchin, Ashley ^{[1
]}

Xu, Ping ^{[1
]}

Najafi, Ron ^{[1
]}

Jain, Rakesh ^{[1
]}

机构：

[1] NovaBay Pharmaceut Inc, Emeryville, CA 94608 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 10期

关键词：

N-Chloroamaines; Antimicrobial agents; Taurine; Minimum bactericidal concentration; Quaternary ammonium; N-CHLOROTAURINE; PHASE-II; TOLERABILITY; CHLORAMINE; TOLERANCE; CHEMISTRY; EFFICACY; MODEL; ACIDS;

D O I：

10.1016/j.bmcl.2009.03.120

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of backbone modified and sulfonic acid replacement analogs of our topical, clinical candidate (iii) were synthesized. Their antimicrobial activities and aqueous stabilities at pH 4 and pH 7 were determined, and has led us to identify quaternary ammonium N,N-dichloroamines as a new class of topical antimicrobial agents. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2731 / 2734

页数：4

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