Synthesis and biological evaluation of some novel tetrahydroquinolines as anticancer and antimicrobial agents

被引：12
|
作者：
Faidallah, Hassan M. [1 ]
Saqer, Alaa A. [1 ]
Alamry, Khalid A. [1 ]
Khan, Khalid A. [1 ]
Asiri, Abdullah M. [1 ,2 ]
机构：
[1] King Abdulaziz Univ, Dept Chem, Fac Sci, Jeddah 21589, Saudi Arabia
[2] King Abdulaziz Univ, Ctr Excellence Adv Mat Res, Jeddah 21589, Saudi Arabia
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2014年 / 29卷 / 03期
关键词：
2-Amino-3-cyano-8-methyl-4-substituted-5,6,7,8-; tetrahydroquinolines; 3H-pyrimido[4,5-b]quinolin-4-ones; antimicrobial agents; cytotoxic agents; POTENT ACTIVITY; IN-VITRO; DERIVATIVES; DESIGN;
D O I：
10.3109/14756366.2013.787421
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study reports the synthesis of a series of new 2-amino-3-cyano-8-methyl-4-substituted-5,6,7,8-tetrahydroquinolines along with some derived fused-ring systems. Ten compounds have shown remarkable cytotoxic activity against human colon carcinoma HT29, hepatocellular carcinoma HepG2 and Caucasian breast adenocarcinoma MCF7 cell lines. Six compounds showed considerable broad-spectrum cytotoxic activity among which two proved to be the most active derivatives. Likewise, seven compounds from the series were found to exhibit significant antimicrobial activity and three of them proved to be the most active candidates. Two alkylthio-pyrimido quinolines are suggested as possible antimicrobial and anticancer candidates in the present series.
引用
收藏
页码：367 / 378
页数：12
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