Cobalt(II)-Catalyzed Oxidative C-H Arylation of Indoles and Boronic Acids

被引：90

作者：

Zhu, Xinju ^{[1
]}

Su, Jian-Hang ^{[1
]}

Du, Cong ^{[1
]}

Wang, Zheng-Long ^{[1
]}

Ren, Chang-Jiu ^{[1
]}

Niu, Jun-Long ^{[1
]}

Song, Mao-Ping ^{[1
]}

机构：

[1] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 03期

基金：

中国国家自然科学基金;

关键词：

CATALYZED DIRECT ARYLATION; BOND ACTIVATION; SELECTIVE ARYLATION; COBALT CATALYSIS; ARYL BROMIDES; FUNCTIONALIZATIONS; CHLORIDES; (HETERO)ARENES; CARBOXAMIDES; ANNULATION;

D O I：

10.1021/acs.orglett.6b03746

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Co(II)-catalyzed C-H C2 selective arylation of indoles with boronic acids through monodentate chelation assistance has been achieved for the first time. The unique features of this methodology include mild reaction conditions, highly C2 regioselectivity, and employment of a Grignard reagent-free catalytic system. A wide range of substrates, including unreactive arenes, are well tolerated, which enables the construction of the coupling products efficiently. This new strategy provides an alternative and versatile approach to construct biaryls using inexpensive cobalt catalyst.

引用

页码：596 / 599

页数：4

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