Inhibition of HSV-1 protease by benzoxazinones

被引：102
|
作者：
Jarvest, RL [1 ]
Parratt, MJ [1 ]
Debouck, CM [1 ]
Gorniak, JG [1 ]
Jennings, LJ [1 ]
Serafinowska, HT [1 ]
Strickler, JE [1 ]
机构：
[1] SMITHKLINE BEECHAM PHARMACEUT,KING OF PRUSSIA,PA 19406
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 20期
关键词：
D O I：
10.1016/0960-894X(96)00455-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Benzoxazinones have been discovered which are mechanism based inhibitors of HSV-1 protease with micromolar IC50 values. Formation of a monoadduct consistent with the acyl-enzyme complex was detected by mass spectroscopy. A parallel array synthesis was developed to explore 2-heteroatom substituted SAR. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：2463 / 2466
页数：4
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