Radiosynthesis of 11-[18F] fluoroundecyltriphenylphosphonium (MitoF) as a potential mitochondria-specific positron emission tomography radiotracer

被引：6
|
作者：
Li, L. [1 ]
Brichard, L. [1 ]
Larsen, L. [2 ]
Menon, D. K. [3 ]
Smith, R. A. J. [2 ]
Murphy, M. P. [4 ]
Aigbirhio, F. I. [1 ]
机构：
[1] Univ Cambridge, Mol Imaging Chem Lab, Wolfson Brain Imaging Ctr, Cambridge, England
[2] Univ Otago, Dept Chem, Dunedin, New Zealand
[3] Univ Cambridge, Div Anaesthesia, Cambridge, England
[4] MRC Mitochondrial Biol Unit, Cambridge, England
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2013年 / 56卷 / 14期
基金：
英国医学研究理事会;
关键词：
triphenylphosphonium; fluorine-18; mitochondria; imaging; MitoF; PET; TARGETED ANTIOXIDANT MITOQ; AGENT; CATION; THERAPEUTICS; THERAPY; DISEASE;
D O I：
10.1002/jlcr.3109
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Changes in the magnitude of the mitochondrial membrane potential occur in a range of important pathologies. To assess changes in membrane potential in patients, we set out to develop an improved mitochondria-targeted positron emission tomography probe comprising a lipophilic triphenylphosphonium cation attached to a fluorine-18 radionuclide via an 11-carbon alkyl chain, which is well-established to effectively transport to and localise within mitochondria. Here, we describe the radiosynthesis of this probe, 11-[F-18]fluoroundecyl-triphenylphosphonium (MitoF), from no-carrier-added [F-18]fluoride and a fully automated synthetic protocol to prepare it in good radiochemical yields (2-3GBq at end-of-synthesis) and radiochemical purity (97-99%). Copyright (c) 2013 John Wiley & Sons, Ltd.
引用
收藏
页码：717 / 721
页数：5
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