Expression of urokinase, plasminogen activator inhibitors and urokinase receptor in pregnant rhesus monkey uterus during early placentation

被引:45
|
作者
Feng, Q
Liu, Y
Liu, K
Byrne, S
Liu, G
Wang, X
Li, Z
Ockelford, CD
机构
[1] Univ Leicester, Sch Med, Dept Preclin Sci, Leicester LE1 9HN, Leics, England
[2] Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100080, Peoples R China
[3] Umea Univ, Dept Med Biochem & Biophys, S-90187 Umea, Sweden
[4] Fujian Inst Parenthood, Fujian 350011, Peoples R China
[5] Nonhuman Primate Res Ctr, Fujian 350011, Peoples R China
基金
英国惠康基金; 中国国家自然科学基金;
关键词
D O I
10.1053/plac.1999.0446
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We have investigated plasmin mediated proteolysis associated with trophoblast invasion during early stages of pregnancy in the rhesus monkey. In situ hybridization and immunocytochemical localization were used to define the cellular and tissue distribution of urokinase plasminogen activator (uPA), plasminogen activator inhibitor type 1 (PAI-1) and 2 (PAI-2) and urokinase receptor in early monkey placenta and uterus. Our results indicate: (1) uPA is expressed in proliferating and invasive cytotrophoblast located in chorionic villi as well as in extravillous trophoblast associated with uterine arterioles, This raises the possibility that urokinase may play an important role in trophoblast invasion. (2) PAI-1 mRNA is specifically localized in two areas where invasive trophoblast cells encounter maternal tissue directly. The extravillous cytotrophoblast cells at the maternofetal junction express PAI-1 mRNA. The invasive endovascular trophoblast cells within the uterine arterioles also express PAI-1 mRNA. The location sensitive expression of PAI-1 mRNA at the maternofetal junction may imply a protective function of this protease inhibitor that might be induced through interaction with decidual cells. (3) Urokinase receptor antigen has also been found at the maternofetal junction and in endovascular trophoblast cells of the invaded maternal blood vessel. (4) PAI-2 immunoreactivity is found in association with cytotrophoblast cells in anchoring choronic villi suggesting ifs association with early placentation. In conclusion, we propose that the plasmin/plasminogen activator system may not only regulate extracellular matrix degradation, bur also modify migration and invasive behaviour of extravillous trophoblast cells, during early placentation. (C) 2000 Harcourt Publishers Ltd.
引用
收藏
页码:184 / 193
页数:10
相关论文
共 50 条
  • [41] Prognostic relevance of urokinase type plasminogen activator, its receptor and inhibitors in chondrosarcoma
    Morii, T
    Yabe, H
    Morioka, H
    Yamada, R
    Nakagawa, T
    Toyama, Y
    ANTICANCER RESEARCH, 2000, 20 (5A) : 3031 - 3036
  • [42] Expression of urokinase type plasminogen activator receptor and plasminogen activator inhibitor-1 in gastric cancer
    Kawasaki, K
    Hayashi, Y
    Wang, Y
    Suzuki, S
    Morita, Y
    Nakamura, T
    Narita, K
    Doe, W
    Itoh, H
    Kuroda, Y
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1998, 13 (09) : 936 - 944
  • [43] Expression of urokinase-type plasminogen activator and its receptor during ovarian follicular development
    Li, M
    Karakji, EG
    Xing, R
    Fryer, JN
    Carnegie, JA
    Rabbani, SA
    Tsang, BK
    ENDOCRINOLOGY, 1997, 138 (07) : 2790 - 2799
  • [44] Elevated urokinase-specific surface receptor expression is maintained through its interaction with urokinase plasminogen activator
    Mahanivong, Chitladda
    Yu, Jianqiang
    Huang, Shuang
    MOLECULAR CARCINOGENESIS, 2007, 46 (03) : 165 - 175
  • [45] EXPRESSION OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR IS INCREASED DURING EPILEPTOGENESIS IN THE RAT HIPPOCAMPUS
    Lahtinen, L.
    Huusko, N.
    Myohanen, H.
    Lehtivarjo, A. -K.
    Pellinen, R.
    Turunen, M. P.
    Yla-Herttuala, S.
    Pirinen, E.
    Pitkanen, A.
    NEUROSCIENCE, 2009, 163 (01) : 316 - 328
  • [46] In vitro activity of probiotic Lactobacillus reuteri against gastric cancer progression by downregulation of urokinase plasminogen activator/urokinase plasminogen activator receptor gene expression
    Rasouli, Bahareh Sadat
    Ghadimi-Darsajini, Ali
    Nekouian, Reza
    Iragian, Gholam-Reza
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2017, 13 (02) : 246 - 251
  • [47] REGULATION OF THE UROKINASE RECEPTOR BY ITS PLASMINOGEN-ACTIVATOR
    HOLLAS, W
    BOYD, D
    THROMBOSIS AND HAEMOSTASIS, 1991, 66 (06) : 678 - 683
  • [48] Intermolecular contact regions in urokinase plasminogen activator receptor
    Liang, OD
    Bdeir, K
    Matz, RL
    Chavakis, T
    Preissner, KT
    JOURNAL OF BIOCHEMISTRY, 2003, 134 (05): : 661 - 666
  • [49] The role of the Urokinase Plasminogen Activator Receptor in severe asthma
    Moseley, C.
    Rankin, G.
    Sayersw, I.
    Howarth, P. H.
    Warner, J. A.
    Holloway, J. W.
    CLINICAL AND EXPERIMENTAL ALLERGY, 2011, 41 (12): : 1828 - 1829
  • [50] Measurement of soluble urokinase plasminogen activator receptor in serum
    Riisbro, R
    Piironen, T
    Brünner, N
    Larsen, B
    Nielsen, HJ
    Stephens, RW
    Hoyer-Hansen, G
    JOURNAL OF CLINICAL LIGAND ASSAY, 2002, 25 (01): : 53 - 56