Modulation of splicing by inhibiting the kinase SRPK1 as a novel therapeutic strategy in myeloid leukemia

被引：0
|
作者：
Tzelepis, Konstantinos
De Braekeleer, Etienne
Seiler, Michael
Barbieri, Isaia
Robson, Sam
Yang, Yu Hsuen
Gozdecka, Malgorzata
Dudek, Monika
Collord, Grace
Dovey, Oliver M.
Metzakopian, Emmanouil
Garyfallos, Dimitrios
Cooper, Jonathan L.
Buonamici, Silvia
Ponstingl, Hannes
Stratton, Michael R.
Bradley, Allan
Huntly, Brian J.
Pina, Cristina
Kouzarides, Tony
Yusa, Kosuke
Vassiliou, George S.
机构：
来源：
CANCER RESEARCH | 2017年 / 77卷
关键词：
D O I：
10.1158/1538-7445.AM2017-1158
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
1158
引用
收藏
页数：2
相关论文
共 50 条
  • [11] Recruiting a Silent Partner for Activation of the Protein Kinase SRPK1
    Aubol, Brandon E.
    Adams, Joseph A.
    BIOCHEMISTRY, 2014, 53 (28) : 4625 - 4634
  • [12] Applying the Brakes to Multisite SR Protein Phosphorylation: Substrate-Induced Effects on the Splicing Kinase SRPK1
    Aubol, Brandon E.
    Adams, Joseph A.
    BIOCHEMISTRY, 2011, 50 (32) : 6888 - 6900
  • [13] SRPK1 Is a Therapeutic Vulnerability in Acute Myeloid Leukemia through Its Effects on Alternative Isoforms of Epigenetic Regulators Including BRD4
    Tzelepis, Konstantinos
    De Braekeleer, Etienne
    Barbieri, Isaia
    Baskar, Vijay
    Aspris, Demetrios
    Prado, Francisco Hermida
    Gozdecka, Malgorzata
    Dudek, Monika
    Postingl, Hannes
    Bates, David
    Bannister, Andrew
    Huntly, Brian J. P.
    Pina, Cristina
    Bradley, Allan
    Yusa, Kosuke
    Kouzarides, Tony
    Vassiliou, George S.
    BLOOD, 2017, 130
  • [14] SRPK1 is a poor prognostic indicator and a novel potential therapeutic target for human colorectal cancer
    Yi, Nan
    Xiao, Mingbing
    Jiang, Feng
    Liu, Zhaoxiu
    Ni, Wenkai
    Lu, Cuihua
    Ni, Runzhou
    Chen, Weichang
    ONCOTARGETS AND THERAPY, 2018, 11 : 5359 - 5370
  • [15] Identification of a novel and potent small molecule inhibitor of SRPK1: mechanism of dual inhibition of SRPK1 for the inhibition of cancer progression
    Chandra, Anshuman
    Ananda, Hanumappa
    Singh, Nagendra
    Qamar, Imteyaz
    AGING-US, 2021, 13 (01): : 163 - 180
  • [16] Human papillomavirus type 16 infection activates the host serine arginine protein kinase 1 (SRPK1) - splicing factor axis
    Mole, Sarah
    Faizo, Arwa Ali A.
    Hernandez-Lopez, Hegel
    Griffiths, Megan
    Stevenson, Andrew
    Roberts, Sally
    Graham, Sheila, V
    JOURNAL OF GENERAL VIROLOGY, 2020, 101 (05): : 523 - 532
  • [17] Nucleotide Release Sequences in the Protein Kinase SRPK1 Accelerate Substrate Phosphorylation
    Aubol, Brandon E.
    Plocinik, Ryan M.
    McGlone, Maria L.
    Adams, Joseph A.
    BIOCHEMISTRY, 2012, 51 (33) : 6584 - 6594
  • [18] SRPK1 acetylation modulates alternative splicing to regulate cisplatin resistance in breast cancer cells
    Cheng Wang
    Zhihong Zhou
    Charannya Sozheesvari Subhramanyam
    Qiong Cao
    Zealyn Shi Lin Heng
    Wen Liu
    Xiangdong Fu
    Qidong Hu
    Communications Biology, 3
  • [19] Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing
    Aubol, Brandon E.
    Wu, Guowei
    Keshwani, Malik M.
    Movassat, Maliheh
    Fattet, Laurent
    Hertel, Klemens J.
    Fu, Xiang-Dong
    Adams, Joseph A.
    MOLECULAR CELL, 2016, 63 (02) : 218 - 228
  • [20] Alternative Splicing in Chronic Myeloid Leukemia (CML): A Novel Therapeutic Target?
    Adamia, Sophia
    Pilarski, Patrick M.
    Bar-Natan, Michal
    Stone, Richard M.
    Griffin, James D.
    CURRENT CANCER DRUG TARGETS, 2013, 13 (07) : 735 - 748
12345