In this paper, we aim to deal with the boundedness and the weak-type boundedness for the generalized fractional integral operators on generalized Orlicz-Morrey spaces of the second kind over non-doubling metric measure spaces, as an extension of [Y. Sawano and T. Shimomura, Boundedness of the generalized fractional integral operators on generalized Morrey spaces over metric measure spaces, Z. Anal. Anwend. 36 (2017), no. 2, 159-190], [Y. Sawano and T. Shimomura, Generalized fractional integral operators over non-doubling metric measure spaces, Integral Transforms Spec. Funct. 28 (2017), no. 7, 534-546] and [I. Sihwaningrum, H. Gunawan and E. Nakai, Maximal and fractional integral operators on generalized Morrey spaces over metric measure spaces, Math. Nachr., to appear].