PET Imaging Quantifying 68Ga-PSMA-11 Uptake in Metastatic Colorectal Cancer

被引：18

作者：

Cuda, Tahleesa J. ^{[1
,2
]}

Riddell, Andrew D. ^{[1
,2
]}

Liu, Cheng ^{[1
,3
,4
]}

Whitehall, Vicki L. ^{[1
,4
]}

Borowsky, Jennifer ^{[1
,2
,4
]}

Wyld, David K. ^{[1
,2
]}

Burge, Matthew E. ^{[1
,2
]}

Ahern, Elizabeth ^{[1
,2
,4
]}

Griffin, Alison ^{[4
]}

Lyons, Nicholas J. R. ^{[1
,2
]}

Rose, Stephen E. ^{[5
]}

Clark, David A. ^{[1
,2
]}

Stevenson, Andrew R. L. ^{[1
,2
]}

Hooper, John D. ^{[1
]}

Puttick, Simon ^{[5
]}

Thomas, Paul A. ^{[1
,2
,6
]}

机构：

[1] Univ Queensland, Brisbane, Qld, Australia

[2] Metro North Hosp & Hlth Serv, Brisbane, Qld, Australia

[3] Envoi Specialist Pathologists, Herston, Qld, Australia

[4] QIMR Berghofer Med Res Inst, Herston, Qld, Australia

[5] CSIRO, Herston, Qld, Australia

[6] Herston Imaging Res Facil, Herston, Qld, Australia

来源：

JOURNAL OF NUCLEAR MEDICINE | 2020年 / 61卷 / 11期

关键词：

metastatic colorectal cancer; peptide receptor radionuclide therapy; PET; theranostics;

D O I：

10.2967/jnumed.119.233312

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

At diagnosis, 22% of colorectal cancer (CRC) patients have metastases, and 50% later develop metastasis. Peptide receptor radionuclide therapy (PRRT), such as Lu-177-PSMA-617, is used to treat metastatic prostate cancer. Lu-177-PSMA-617 targets prostate-specific membrane antigen (PSMA), a cell-surface protein enriched in prostate cancer and the neovasculature of other solid tumors, including CRC. We performed Ga-68-PSMA-11 PET/CT imaging of 10 patients with metastatic CRC to assess metastasis avidity. Eight patients had lesions lacking avidity, and 2 had solitary metastases exhibiting very low avidity. Despite expression of PSMA in CRC neovasculature, none of the patients exhibited tumor avidity sufficient to be considered for Lu-177-PSMA-617 PRRT.

引用

页码：1576 / 1579

页数：4

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