PET Imaging Quantifying 68Ga-PSMA-11 Uptake in Metastatic Colorectal Cancer

被引：18
|
作者：
Cuda, Tahleesa J. [1 ,2 ]
Riddell, Andrew D. [1 ,2 ]
Liu, Cheng [1 ,3 ,4 ]
Whitehall, Vicki L. [1 ,4 ]
Borowsky, Jennifer [1 ,2 ,4 ]
Wyld, David K. [1 ,2 ]
Burge, Matthew E. [1 ,2 ]
Ahern, Elizabeth [1 ,2 ,4 ]
Griffin, Alison [4 ]
Lyons, Nicholas J. R. [1 ,2 ]
Rose, Stephen E. [5 ]
Clark, David A. [1 ,2 ]
Stevenson, Andrew R. L. [1 ,2 ]
Hooper, John D. [1 ]
Puttick, Simon [5 ]
Thomas, Paul A. [1 ,2 ,6 ]
机构：
[1] Univ Queensland, Brisbane, Qld, Australia
[2] Metro North Hosp & Hlth Serv, Brisbane, Qld, Australia
[3] Envoi Specialist Pathologists, Herston, Qld, Australia
[4] QIMR Berghofer Med Res Inst, Herston, Qld, Australia
[5] CSIRO, Herston, Qld, Australia
[6] Herston Imaging Res Facil, Herston, Qld, Australia
来源：
JOURNAL OF NUCLEAR MEDICINE | 2020年 / 61卷 / 11期
关键词：
metastatic colorectal cancer; peptide receptor radionuclide therapy; PET; theranostics;
D O I：
10.2967/jnumed.119.233312
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
At diagnosis, 22% of colorectal cancer (CRC) patients have metastases, and 50% later develop metastasis. Peptide receptor radionuclide therapy (PRRT), such as Lu-177-PSMA-617, is used to treat metastatic prostate cancer. Lu-177-PSMA-617 targets prostate-specific membrane antigen (PSMA), a cell-surface protein enriched in prostate cancer and the neovasculature of other solid tumors, including CRC. We performed Ga-68-PSMA-11 PET/CT imaging of 10 patients with metastatic CRC to assess metastasis avidity. Eight patients had lesions lacking avidity, and 2 had solitary metastases exhibiting very low avidity. Despite expression of PSMA in CRC neovasculature, none of the patients exhibited tumor avidity sufficient to be considered for Lu-177-PSMA-617 PRRT.
引用
收藏
页码：1576 / 1579
页数：4
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