Association of FEV1 in asthmatic children with personal and microenvironmental exposure to airborne particulate matter

被引:180
|
作者
Delfino, RJ
Quintana, PJE
Floro, J
Gastañaga, VM
Samimi, BS
Kleinman, MT
Liu, LJS
Bufalino, C
Wu, CF
McLaren, CE
机构
[1] Univ Calif Irvine, Coll Med, Dept Med, Div Epidemiol, Irvine, CA 92697 USA
[2] San Diego State Univ, Grad Sch Publ Hlth, Div Occupat & Environm Hlth, San Diego, CA 92182 USA
[3] Univ Calif Irvine, Coll Med, Dept Community & Environm Med, Irvine, CA 92717 USA
[4] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA
关键词
asthma; epidemiology; forced expiratory volume; longitudinal data analysis; nitrogen dioxide; ozone; panel study; particulate air pollution;
D O I
10.1289/ehp.6815
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Exposure to particulate matter (PM) air pollution has been shown to exacerbate children's asthma, but the exposure sources and temporal characteristics are still under study. Children's exposure to PM is likely to involve both combustion-related ambient PM and PM related to a child's activity in various indoor and outdoor microenvironments. Among 19 children with asthma, 9-17 years of age, we examined the relationship of temporal changes in percent predicted forced expiratory volume in 1 sec (FEV1) to personal continuous PM exposure and to 24-hr average gravimetric PM mass measured at home and central sites. Subjects were followed for 2 weeks during either the fall of 1999 or the spring of 2000, in a southern California region affected by transported air pollution. FEV1 was measured by subjects in the morning, afternoon, and evening. Exposure measurements included continuous PM using a passive nephelometer carried by subjects; indoor, outdoor home, and central-site 24-hr gravimetric PM2.5 (PM of aerodynamic diameter < 2.5 mum) and PM10; and central-site hourly PM10, nitrogen dioxide, and ozone. Data were analyzed with linear mixed models controlling for within-subject autocorrelation, FEV1 maneuver time, and exposure period. We found inverse associations of FEV1 with increasing PM exposure during the 24 hr before the FEV1 maneuver and with increasing multiday PM averages. Deficits in percent predicted FEV1 (95% confidence interval) for given PM interquartile ranges measured during the preceding 24-hr were as follows: 128 mug/m(3) 1-hr maximum personal PM, -6.0% (-10.5 to -1.4); 30 mug/m(3) 24-hr average personal PM, -5.9% (-10.8 to -1.0); 6.7 mug/m(3) indoor home PM2.5, -1.6% (-2.8 to -0.4); 16 mug/m(3) indoor home PM10, -2.1% (-3.7 to -0.4); 7.1 mug/m(3) outdoor home PM2.5, -1-1% (-2.4 to 0.1); and 7.5 mug/m(3) central-site P-M2.5, -0.7% (-1.9 to 0.4). Stronger associations were found for multiday moving averages of PM for both personal and stationary-site PM. Stronger associations with personal PM were found in boys allergic to indoor allergens. FEV1 was weakly associated with NO2 but not with O-3. Results suggest mixed respiratory effects of PM in asthmatic children from both ambient background exposures and personal exposures in various microenvironments.
引用
收藏
页码:932 / 941
页数:10
相关论文
共 50 条
  • [31] Characterization of exposure to particulate matter and it's components for asthmatic children in an urban environment
    Keeler, GJ
    Yip, FY
    Dvonch, JT
    Parker, EA
    Robins, TG
    Brakefield-Caldwell, W
    EPIDEMIOLOGY, 2002, 13 (04) : S134 - S134
  • [32] Relative value of FEV1 and FEV1%FVC in evaluating control of asthma in children and young adults
    Ciolkowski, J.
    Henryk, M.
    Stasiowska, B.
    ALLERGY, 2009, 64 : 303 - 303
  • [33] Effect of Different Positions on FVC and FEV1 Measurements of Asthmatic Patients
    Melam, Ganeswara Rao
    Buragadda, Syamala
    Alhusaini, Adel
    Alghamdi, Mohamm Ed Abdulrahman
    Alghamdi, Mansour Saleh
    Kaushal, Parmveer
    JOURNAL OF PHYSICAL THERAPY SCIENCE, 2014, 26 (04) : 591 - 593
  • [34] Concordance between the Piko-1® portable device and pneumotachography in measuring PEF and FEV1 in asthmatic children
    Aguilar-Fernandez, A. J.
    Villa-Asensi, J. R.
    Castro-Codesal, M.
    Almeria-Gil, E.
    Gonzalez-Alvarez, M. I.
    Romero-Andujar, F.
    ALLERGOLOGIA ET IMMUNOPATHOLOGIA, 2009, 37 (05) : 244 - 248
  • [35] Reinventing personal exposure to particulate matter
    Mage, D
    Wilson, W
    EPIDEMIOLOGY, 1999, 10 (04) : S65 - S65
  • [36] Obstructive sleep apnoea accelerates FEV1 decline in asthmatic patients
    Wang, Tsai-Yu
    Lo, Yu-Lun
    Lin, Shu-Min
    Huang, Chien-Da
    Chung, Fu-Tasi
    Lin, Horng-Chyuan
    Wang, Chun-Hua
    Kuo, Han-Pin
    BMC PULMONARY MEDICINE, 2017, 17
  • [37] The association of exposure to fine airborne particulate matter with cardiovascular diseases in Beirut Lebanon
    Zgheib, N. K.
    Imad, A.
    Ismaeel, H.
    Badr, K.
    Saliba, N.
    Lakkis, I.
    TOXICOLOGY LETTERS, 2019, 314 : S103 - S103
  • [38] Obstructive sleep apnoea accelerates FEV1 decline in asthmatic patients
    Tsai-Yu Wang
    Yu-Lun Lo
    Shu-Min Lin
    Chien-Da Huang
    Fu-Tasi Chung
    Horng-Chyuan Lin
    Chun-Hua Wang
    Han-Pin Kuo
    BMC Pulmonary Medicine, 17
  • [39] Association of Post-WTC-mortality With Normal Pre-exposure FEV1
    Weiden, M. D.
    Zeig-Owens, R.
    Hall, C. B.
    Choi, J.
    Prezant, D. J.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2023, 207
  • [40] Exposure to airborne particulate matter in the subway system
    Martins, Vania
    Moreno, Teresa
    Cruz Minguillon, Maria
    Amato, Fulvio
    de Miguel, Eladio
    Capdevila, Marta
    Querol, Xavier
    SCIENCE OF THE TOTAL ENVIRONMENT, 2015, 511 : 711 - 722