asthma;
epidemiology;
forced expiratory volume;
longitudinal data analysis;
nitrogen dioxide;
ozone;
panel study;
particulate air pollution;
D O I:
10.1289/ehp.6815
中图分类号:
X [环境科学、安全科学];
学科分类号:
08 ;
0830 ;
摘要:
Exposure to particulate matter (PM) air pollution has been shown to exacerbate children's asthma, but the exposure sources and temporal characteristics are still under study. Children's exposure to PM is likely to involve both combustion-related ambient PM and PM related to a child's activity in various indoor and outdoor microenvironments. Among 19 children with asthma, 9-17 years of age, we examined the relationship of temporal changes in percent predicted forced expiratory volume in 1 sec (FEV1) to personal continuous PM exposure and to 24-hr average gravimetric PM mass measured at home and central sites. Subjects were followed for 2 weeks during either the fall of 1999 or the spring of 2000, in a southern California region affected by transported air pollution. FEV1 was measured by subjects in the morning, afternoon, and evening. Exposure measurements included continuous PM using a passive nephelometer carried by subjects; indoor, outdoor home, and central-site 24-hr gravimetric PM2.5 (PM of aerodynamic diameter < 2.5 mum) and PM10; and central-site hourly PM10, nitrogen dioxide, and ozone. Data were analyzed with linear mixed models controlling for within-subject autocorrelation, FEV1 maneuver time, and exposure period. We found inverse associations of FEV1 with increasing PM exposure during the 24 hr before the FEV1 maneuver and with increasing multiday PM averages. Deficits in percent predicted FEV1 (95% confidence interval) for given PM interquartile ranges measured during the preceding 24-hr were as follows: 128 mug/m(3) 1-hr maximum personal PM, -6.0% (-10.5 to -1.4); 30 mug/m(3) 24-hr average personal PM, -5.9% (-10.8 to -1.0); 6.7 mug/m(3) indoor home PM2.5, -1.6% (-2.8 to -0.4); 16 mug/m(3) indoor home PM10, -2.1% (-3.7 to -0.4); 7.1 mug/m(3) outdoor home PM2.5, -1-1% (-2.4 to 0.1); and 7.5 mug/m(3) central-site P-M2.5, -0.7% (-1.9 to 0.4). Stronger associations were found for multiday moving averages of PM for both personal and stationary-site PM. Stronger associations with personal PM were found in boys allergic to indoor allergens. FEV1 was weakly associated with NO2 but not with O-3. Results suggest mixed respiratory effects of PM in asthmatic children from both ambient background exposures and personal exposures in various microenvironments.
机构:
King Saud Univ, Dept Rehabil Sci, Coll Appl Med Sci, Riyadh 11433, Saudi ArabiaKing Saud Univ, Dept Rehabil Sci, Coll Appl Med Sci, Riyadh 11433, Saudi Arabia
Melam, Ganeswara Rao
Buragadda, Syamala
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King Saud Univ, Dept Rehabil Sci, Coll Appl Med Sci, Riyadh 11433, Saudi ArabiaKing Saud Univ, Dept Rehabil Sci, Coll Appl Med Sci, Riyadh 11433, Saudi Arabia
Buragadda, Syamala
Alhusaini, Adel
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King Saud Univ, Dept Rehabil Sci, Coll Appl Med Sci, Riyadh 11433, Saudi ArabiaKing Saud Univ, Dept Rehabil Sci, Coll Appl Med Sci, Riyadh 11433, Saudi Arabia
Alhusaini, Adel
Alghamdi, Mohamm Ed Abdulrahman
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King Saud Univ, Dept Rehabil Sci, Coll Appl Med Sci, Riyadh 11433, Saudi ArabiaKing Saud Univ, Dept Rehabil Sci, Coll Appl Med Sci, Riyadh 11433, Saudi Arabia
Alghamdi, Mohamm Ed Abdulrahman
Alghamdi, Mansour Saleh
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King Saud Univ, Dept Rehabil Sci, Coll Appl Med Sci, Riyadh 11433, Saudi ArabiaKing Saud Univ, Dept Rehabil Sci, Coll Appl Med Sci, Riyadh 11433, Saudi Arabia
Alghamdi, Mansour Saleh
Kaushal, Parmveer
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机构:
SPS Apollo Hosp, Physiotherapy Dept, Ludhiana, Punjab, IndiaKing Saud Univ, Dept Rehabil Sci, Coll Appl Med Sci, Riyadh 11433, Saudi Arabia