Time and Technology Will Tell The Pathophysiologic Basis of Neurohormonal Modulation in Heart Failure

被引：12

作者：

Reed, Brent N. ^{[1
]}

Street, Sarah E. ^{[2
]}

Jensen, Brian C. ^{[3
,4
]}

机构：

[1] Univ Maryland, Sch Pharm, Dept Pharm Practice & Sci, Baltimore, MD 21201 USA

[2] Univ N Carolina, Sch Med, Dept Cell Biol & Physiol, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Sch Med, Div Cardiol, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Sch Med, McAllister Heart Inst, Chapel Hill, NC 27599 USA

来源：

HEART FAILURE CLINICS | 2014年 / 10卷 / 04期

关键词：

Heart failure; Sympathetic nervous system; Renin-angiotensin system; Drug therapy; Physiology; Neurotransmitter agents; Adrenergic beta-antagonists; Angiotensin-converting enzyme inhibitors; LEFT-VENTRICULAR DYSFUNCTION; CONVERTING-ENZYME-INHIBITORS; ACUTE MYOCARDIAL-INFARCTION; SUSTAINED-RELEASE MOXONIDINE; NATRIURETIC PEPTIDE SYSTEM; SYMPATHETIC-NERVE ACTIVITY; BETA-ADRENERGIC-BLOCKADE; LONG-TERM TREATMENT; ANGIOTENSIN-II; RECEPTOR BLOCKADE;

D O I：

10.1016/j.hfc.2014.07.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The central roles of neurohormonal abnormalities in the pathobiology of heart failure have been defined in recent decades. Experiments have revealed both systemic involvement and intricate subcellular regulation by circulating effectors of the sympathetic nervous system, the renin-angiotensin-aldosterone system, and others. Randomized clinical trials substantiated these findings, establishing neurohormonal antagonists as cornerstones of heart failure pharmacotherapy, and occasionally offering further insight on mode of benefit. This review discusses the use of beta-blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and aldosterone receptor antagonists in the treatment of heart failure, with particular attention to the pathophysiologic basis and mechanisms of action.

引用

页码：543 / +

页数：16

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