MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy

被引：25
|
作者：
Umerez, Maitane [1 ]
Gutierrez-Camino, Angela [1 ]
Munoz-Maldonado, Carmen [1 ]
Martin-Guerrero, Idoia [1 ]
Garcia-Orad, Africa [1 ,2 ]
机构：
[1] Univ Basque Country, Fac Med & Nursery, Dept Genet Phys Anthropol & Anim Physiol, UPV EHU,Barrio Sarriena S-N, Leioa, Spain
[2] BioCruces Hlth Res Inst, Baracaldo, Spain
来源：
PHARMACOGENOMICS & PERSONALIZED MEDICINE | 2017年 / 10卷
关键词：
MTHFR; methotrexate; toxicity; outcome; C677T; A1298C; METHYLENETETRAHYDROFOLATE REDUCTASE C677T; GENETIC POLYMORPHISMS; TURKISH CHILDREN; CANDIDATE GENES; RISK-FACTORS; TOXICITY; PHARMACOGENETICS; ASSOCIATION; PREDICTION; PROGNOSIS;
D O I：
10.2147/PGPM.S107047
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia ( ALL). Methylenetetrahydrofolate reductase ( MTHFR) is a key enzyme for MTX pharmacokinetics. Two single-nucleotide polymorphisms in MTHFR gene, C677T and A1298C, affecting MTHFR activity, have been widely studied as potential markers of MTX toxicity and/or outcome in pediatric ALL. In this review, we show that the majority of published reports do not find association or present opposite effect. Therefore, MTHFR C677T and A1298C polymorphisms do not seem to be good markers of MTX-related toxicity and/or outcome in pediatric ALL. The efforts should be focused on other genes, such as transporter genes or microRNA-related genes.
引用
收藏
页码：69 / 78
页数：10
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