MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy

被引：25
|
作者：
Umerez, Maitane [1 ]
Gutierrez-Camino, Angela [1 ]
Munoz-Maldonado, Carmen [1 ]
Martin-Guerrero, Idoia [1 ]
Garcia-Orad, Africa [1 ,2 ]
机构：
[1] Univ Basque Country, Fac Med & Nursery, Dept Genet Phys Anthropol & Anim Physiol, UPV EHU,Barrio Sarriena S-N, Leioa, Spain
[2] BioCruces Hlth Res Inst, Baracaldo, Spain
来源：
PHARMACOGENOMICS & PERSONALIZED MEDICINE | 2017年 / 10卷
关键词：
MTHFR; methotrexate; toxicity; outcome; C677T; A1298C; METHYLENETETRAHYDROFOLATE REDUCTASE C677T; GENETIC POLYMORPHISMS; TURKISH CHILDREN; CANDIDATE GENES; RISK-FACTORS; TOXICITY; PHARMACOGENETICS; ASSOCIATION; PREDICTION; PROGNOSIS;
D O I：
10.2147/PGPM.S107047
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia ( ALL). Methylenetetrahydrofolate reductase ( MTHFR) is a key enzyme for MTX pharmacokinetics. Two single-nucleotide polymorphisms in MTHFR gene, C677T and A1298C, affecting MTHFR activity, have been widely studied as potential markers of MTX toxicity and/or outcome in pediatric ALL. In this review, we show that the majority of published reports do not find association or present opposite effect. Therefore, MTHFR C677T and A1298C polymorphisms do not seem to be good markers of MTX-related toxicity and/or outcome in pediatric ALL. The efforts should be focused on other genes, such as transporter genes or microRNA-related genes.
引用
收藏
页码：69 / 78
页数：10
相关论文
共 50 条
  • [1] The influence of MTHFR genetic polymorphisms on methotrexate therapy in pediatric acute lymphoblastic leukemia
    Shen, Yaqing
    Wang, Zhujun
    Zhou, Fen
    Jin, Runming
    OPEN LIFE SCIENCES, 2021, 16 (01): : 1203 - 1212
  • [2] MTHFR genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia
    Thirumaran, RK
    Gast, A
    Flohr, T
    Burwinkel, B
    Bartram, C
    Hemminki, K
    Kumar, R
    BLOOD, 2005, 106 (07) : 2590 - 2591
  • [3] Update on MTHFR Pharmacogenetics and Methotrexate Toxicity in Childhood Acute Lymphoblastic Leukemia
    Lopez-Lopez, E.
    Martin-Guerrero, I.
    Ballesteros, J.
    Uriz, J.
    Pinan, M. A.
    Garcia-Miguel, P.
    Navajas, A.
    Garcia-Orad, A.
    EUROPEAN JOURNAL OF CANCER, 2011, 47 : S286 - S286
  • [4] MTHFR polymorphisms' influence on outcome and toxicity in acute lymphoblastic leukemia patients
    Chiusolo, Patrizia
    Reddiconto, Giovanni
    Farina, Giuliana
    Mannocci, Alice
    Fiorini, Alessia
    Palladino, Mariangela
    La Torre, Giuseppe
    Fianchi, Luana
    Sora, Federica
    Laurenti, Luca
    Leone, Giuseppe
    Sica, Simona
    LEUKEMIA RESEARCH, 2007, 31 (12) : 1669 - 1674
  • [5] MTHFR POLYMORPHISMS ARE ASSOCIATED WITH MTX TOXICITY AND OUTCOME IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA
    Indolfi, Paolo
    D'Angelo, Velia
    Francese, Matteo
    Iannotta, Adriana
    Pecoraro, Giulia
    Ramaglia, Maria
    Fusco, Claudia
    Pota, Elvira
    Di Pinto, Daniela
    Oreste, Matilde
    Indolfi, Cristiana
    Casale, Fiorina
    PEDIATRIC BLOOD & CANCER, 2009, 53 (05) : 726 - 726
  • [6] Polymorphisms in methylenetetrahydrofolate reductase and methotrexate sensitivity in childhood acute lymphoblastic leukemia
    JW Taub
    LH Matherly
    Y Ravindranath
    G-J L Kaspers
    MG Rots
    CH Zantwijk
    Leukemia, 2002, 16 : 764 - 765
  • [7] Polymorphisms in methylenetetrahydrofolate reductase and methotrexate sensitivity in childhood acute lymphoblastic leukemia
    Taub, JW
    Matherly, LH
    Ravindranath, Y
    Kaspers, GJL
    Rots, MG
    van Zantwijk, CH
    LEUKEMIA, 2002, 16 (04) : 764 - 765
  • [8] Influence of genetic polymorphisms of FPGS, GGH, and MTHFR on serum methotrexate levels in Chinese children with acute lymphoblastic leukemia
    Wang, Shu-mei
    Sun, Lu-lu
    Zeng, Wei-xin
    Wu, Wan-shui
    Zhang, Guo-liang
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2014, 74 (02) : 283 - 289
  • [9] Influence of genetic polymorphisms of FPGS, GGH, and MTHFR on serum methotrexate levels in Chinese children with acute lymphoblastic leukemia
    Shu-mei Wang
    Lu-lu Sun
    Wei-xin Zeng
    Wan-shui Wu
    Guo-liang Zhang
    Cancer Chemotherapy and Pharmacology, 2014, 74 : 283 - 289
  • [10] THE INFLUENCE OF METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) POLYMORPHISMS ON THE SEVERITY OF MEDIUM DOSE-METHOTREXATE INFUSION RELATED TOXICITY AND PROGNOSIS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA
    Karakukcu, M.
    Unal, E.
    Mutlu, F.
    Ozdemir, M.
    Patiroglu, T.
    Ozkul, Y.
    HAEMATOLOGICA, 2012, 97 : 489 - 489
12345