Therapeutic aspects of the Axl/Gas6 molecular system

被引：29
|
作者：
Di Stasi, Rossella [1 ]
De Rosa, Lucia [1 ]
D'Andrea, Luca D. [2 ]
机构：
[1] CNR, Ist Biostrutture & Bioimmagini, Via Mezzocannone 16, I-80134 Naples, Italy
[2] CNR, Ist Biostrutture & Bioimmagini, Via Nizza 52, I-10126 Turin, Italy
来源：
DRUG DISCOVERY TODAY | 2020年 / 25卷 / 12期
关键词：
RECEPTOR TYROSINE KINASE; MYELOID-LEUKEMIA CELLS; ARREST-SPECIFIC GENE-6; GROWTH-FACTOR RECEPTOR; ZIKA VIRUS-INFECTION; PROTEIN; 6; GAS6; AXL KINASE; TAM RECEPTORS; TUMOR-GROWTH; PLASMA-CONCENTRATIONS;
D O I：
10.1016/j.drudis.2020.09.022
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Axl receptor tyrosine kinase (RTK) and its ligand, growth arrest-specific protein 6 (Gas6), are involved in several biological functions and participate in the development and progression of a range of malignancies and autoimmune disorders. In this review, we present this molecular system from a drug discovery perspective, highlighting its therapeutic implications and challenges that need to be addressed. We provide an update on Axl/Gas6 axis biology, exploring its role in fields ranging from angiogenesis, cancer development and metastasis, immune response and inflammation to viral infection. Finally, we summarize the molecules that have been developed to date to target the Axl/Gas6 molecular system for and
引用
收藏
页码：2130 / 2148
页数：19
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