Mid- and long-term outcome of 89 premature infants weighing less than 1,000 g at birth, all appropriate for gestational age

Objective: Advances in obstetrical and neonatal care have achieved dramatic reductions in the mortality of extremely low birth weight Infants, but concerns regarding the long-term neurodevelopmental prognosis have increased. The study was performed to assess the physical and neurodevelopmental status of premature infants weighing < 1,000 g at birth who were appropriate for gestational age (AGA). Methods: A follow-up study including school level. physical and developmental examination and/or interviews of parents, pediatricians, teachers and social workers was carried out from January 1, 1981 to December 31, 1991, on 176 subjects who had been AGA premature neonates weighing < 1,000 g and were admitted to the Port Royal Neonatal Intensive Care Unit. Eighty-nine survived (50 girls, 39 boys). Five children were lost to follow-up after 3 years of age. Neurological sequelae, developmental and/or intellectual quotients, school level and results, vision, hearing, language, weight, height, and behavior were evaluated. Results: At the last evaluation, 37% of children were completely normal (24% had always been normal); 52% were normal in the 4th year of life, decreasing to 31% in the 8th year. Minor disabilities increased from 31% in the 4th year to 53% in the 8th year. Moderate disabilities ranged yearly between 8 and 14%. Five children had major handicaps diagnosed before 3 years of age (4 cerebral palsies following severe neonatal brain lesions and 1 severe retardation with renal dwarfism). No difference was found between children with or without bronchopulmonary dysplasia. Twelve children (14%) had hearing loss (3 deafness) and 27 (32%) had visual deficits (no blindness). Nursery school begins at 3 for French children: 86% of the followed survivors were al nursery school at 3 years of age, 74% of 6-year-olds were in the first grade, primary school, and 50% of 7-year-olds were in second grade. Half the children with high socioeconomic/cultural risks had some school difficulties. Similar results were collected from various cross-sectional studies in the recent literature. Conclusions: While 20% of the children had moderate to severe disabilities. an increasing number of minor deficiencies appeared with age, Socioeconomic/cultural factors had a deleterious effect even in structurally normal children, but they had an even worse effect in children with minor deficiencies. owing largely to the frequent lack of proper management at home.