Passerini Multicomponent Reaction of Indane-1,2,3-Trione: an Efficient Route for the One-Pot Synthesis of Sterically Congested 2,2-Disubstituted Indane-1,3-Dione Derivatives

被引：65
|
作者：
Kazemizadeh, Ali Reza [1 ]
Ramazani, Ali [1 ]
机构：
[1] Zanjan Univ, Dept Chem, Zanjan, Iran
来源：
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2009年 / 20卷 / 02期
关键词：
indane-1,2,3-trione; isocyanide; Passerini reaction; benzoic acid; DIALKYL ACETYLENEDICARBOXYLATES; STEREOSELECTIVE-SYNTHESIS; ALPHA-AMINOALDEHYDES; 3-COMPONENT REACTION; ISOCYANIDES; CHEMISTRY; (N-ISOCYANIMINO)TRIPHENYLPHOSPHORANE; INHIBITORS; ACID;
D O I：
10.1590/S0103-50532009000200016
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The Passerini reaction of indane-1,2,3-trione, isocyanides and benzoic acid derivatives proceed at room temperature and sterically congested 2,2-disubstituted indane-1,3-dione derivatives are synthesized in excellent yields. The reaction proceeds smoothly and cleanly under mild conditions and no side reactions are observed.
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页码：309 / 312
页数：4
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