QSAR MODELLING OF SELECTIVE CC CHEMOKINE RECEPTOR 3 (CCR3) ANTAGONISTS USING PHYSICOCHEMICAL PARAMETERS

被引：0
|
作者：
Srivastava, A. K. [1 ]
Jaiswal, M. [1 ]
Archana [1 ]
Srivasvata, A. [1 ]
机构：
[1] Univ Allahabad, Dept Chem, QSAR Res Lab, Allahabad 211002, Uttar Pradesh, India
来源：
OXIDATION COMMUNICATIONS | 2009年 / 32卷 / 01期
关键词：
QSAR; chemokine receptor 3 (CCR3) antagonists; REGRESSION;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
QSAR studies on selective CC chemokine receptor 3 antagonists (CCR3) and their activity are reported. The statistical techniques were applied to identify the structural and physicochemical requirements for binding affinities and transporter selectivity profiles for selected N.-substituted piperidines ureas. It has been found that steric, hydrophobic and electrostatic parameters along with indicator variables are significantly correlated with activity.
引用
收藏
页码：55 / 61
页数：7
相关论文
共 50 条
  • [31] Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2
    Dhanak, D
    Christmann, LT
    Darcy, MG
    Keenan, RM
    Knight, SD
    Lee, J
    Ridgers, LH
    Sarau, HM
    Shah, DH
    White, JR
    Zhang, LL
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (11) : 1445 - 1450
  • [32] In Silico Identification of Cholesterol Binding Motifs in the Chemokine Receptor CCR3
    van Aalst, Evan
    Koneri, Jotham
    Wylie, Benjamin J.
    [J]. MEMBRANES, 2021, 11 (08)
  • [33] Conserved sequence and tissue expression of the rat CCR3 chemokine receptor
    Flanagan, BF
    Harrington, PM
    Newton, DJ
    Coleman, JW
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1998, 101 (01) : S42 - S43
  • [34] Chemokine receptor CCR3 is important for migration of mast cells in neurofibroma
    Tai, Wei-Chun
    Wang, Sin-Ting
    Wu, Chieh-Shan
    Lin, Tze-Yi
    Wu, Meng-Tse
    [J]. DERMATOLOGICA SINICA, 2010, 28 (04) : 146 - 153
  • [35] Functional analysis of the chemokine receptor CCR3 on airway epithelial cells
    Beck, Lisa A.
    Tancowny, Brian
    Brummet, Mary E.
    Asaki, S. Yukiko
    Curry, Stephanie L.
    Penno, Margaret B.
    Foster, Martyn
    Bahl, Ash
    Stellato, Cristiana
    [J]. JOURNAL OF IMMUNOLOGY, 2006, 177 (05): : 3344 - 3354
  • [36] Expression of the chemokine eotaxin and its receptor, CCR3, in human endometrium
    Zhang, J
    Lathbury, LJ
    Salamonsen, LA
    [J]. BIOLOGY OF REPRODUCTION, 2000, 62 (02) : 404 - 411
  • [37] The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3
    Loetscher, P
    Pellegrino, A
    Gong, JH
    Mattioli, I
    Loetscher, M
    Bardi, G
    Baggiolini, M
    Clark-Lewis, I
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (05) : 2986 - 2991
  • [38] Detection of the chemokine receptor CCR3 on endothelial cells and keratinocytes.
    Lee, SC
    Brummet, ME
    Sholl, L
    Plitt, JR
    MacGlashan, DW
    Ponath, PD
    Schleimer, RP
    Beck, LA
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 103 (01) : S194 - S194
  • [39] A model system for inducible expression of the CC chemokine receptors CCR1, CCR3, and CCR8.
    Tiffany, HL
    Alkhatib, G
    Combadiere, C
    Berger, EA
    Murphy, PM
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 1997, : 3 - 3
  • [40] Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3, and CCR5
    Pakianathan, DR
    Kuta, EG
    Artis, DR
    Skelton, NJ
    Hebert, CA
    [J]. BIOCHEMISTRY, 1997, 36 (32) : 9642 - 9648
12345