QSAR MODELLING OF SELECTIVE CC CHEMOKINE RECEPTOR 3 (CCR3) ANTAGONISTS USING PHYSICOCHEMICAL PARAMETERS

被引：0
|
作者：
Srivastava, A. K. [1 ]
Jaiswal, M. [1 ]
Archana [1 ]
Srivasvata, A. [1 ]
机构：
[1] Univ Allahabad, Dept Chem, QSAR Res Lab, Allahabad 211002, Uttar Pradesh, India
来源：
OXIDATION COMMUNICATIONS | 2009年 / 32卷 / 01期
关键词：
QSAR; chemokine receptor 3 (CCR3) antagonists; REGRESSION;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
QSAR studies on selective CC chemokine receptor 3 antagonists (CCR3) and their activity are reported. The statistical techniques were applied to identify the structural and physicochemical requirements for binding affinities and transporter selectivity profiles for selected N.-substituted piperidines ureas. It has been found that steric, hydrophobic and electrostatic parameters along with indicator variables are significantly correlated with activity.
引用
收藏
页码：55 / 61
页数：7
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