A new dineolignan with anti-β-amyloid aggregation activity from the fruits of crataegus pinnatifida bge

被引：8
|
作者：
Zhao, Peng [1 ]
Lou, Li-Li [1 ]
Zhang, Hao [1 ]
Guo, Rui [1 ]
Wang, Xiao-Bo [2 ]
Huang, Xiao-Xiao [1 ,2 ]
Song, Shao-Jiang [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Computat Chem Based Nat Antitumor Drug Re, Shenyang 110016, Peoples R China
[2] Chinese Peoples Liberat Army Logist Support Force, Dalian 116021, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 12期
关键词：
Crataegus pinnatifida; dineolignan; structure elucidation; A beta(1-42) aggregation; NEOLIGNANS;
D O I：
10.1080/14786419.2019.1655415
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new dineolignan, crataeguslignan A (1), along with one known dineolignan (2) were isolated from the fruits of Crataegus pinnatifida Bge. Its chemical structure was identified by comprehensive spectroscopic analyses. All the isolated compounds were investigated with regard to their A beta(1-42) inhibition activity. Among them, 1 displayed the most potent A beta(1-42) inhibitory ability with the inhibition rate of 85.2% at the concentration of 20 mu M.
引用
收藏
页码：2112 / 2115
页数：4
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