Polyketides with New Delhi Metallo-β-lactamase 1 Inhibitory Activity from Penicillium sp.

被引：37

作者：

Gan, Maoluo ^{[1
,2
,3
]}

Liu, Yufeng ^{[2
,3
,4
]}

Bai, Yinlei ^{[1
,2
]}

Guan, Yan ^{[1
,2
]}

Li, Li ^{[2
,3
]}

Gao, Rongmei ^{[1
,2
]}

He, Weiying ^{[1
,2
]}

You, Xuefu ^{[1
,2
]}

Li, Yuhuan ^{[1
,2
]}

Yu, Liyan ^{[1
,2
]}

Xiao, Chunling ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[4] Jining Med Coll, Jining 272067, Shandong, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 09期

基金：

北京市自然科学基金;

关键词：

BIOSYNTHESIS; METABOLITES; POLIVIONE; ENTEROBACTERIACEAE; STREPTOTHRICINS; CITROMYCETIN; THEOBROXIDE; DERIVATIVES; FREQUENTANS; PRODUCTS;

D O I：

10.1021/np4000944

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new polyketide compounds (1-3), a new quinolone alkaloid (4), and seven known polyketide derivatives were identified from the cultures of Penicillium sp. I09F 484, a strain isolated from the rhizosphere soil of the plant Picea asperata from Kanas Lake, Xinjiang, China. Their structures were elucidated by extensive spectroscopic data analysis. The absolute configurations of 1 and 4 were established by quantum chemical time-dependent density functional theory electronic circular dichroism calculation and Marfey's method, respectively. Compounds 1 and 2 displayed inhibitory activity against New Delhi metallo-beta-lactamase 1 with IC50 values of 94.9 and 87.9 mu M, respectively.

引用

页码：1535 / 1540

页数：6

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