Polyketides with New Delhi Metallo-β-lactamase 1 Inhibitory Activity from Penicillium sp.

被引：37
|
作者：
Gan, Maoluo [1 ,2 ,3 ]
Liu, Yufeng [2 ,3 ,4 ]
Bai, Yinlei [1 ,2 ]
Guan, Yan [1 ,2 ]
Li, Li [2 ,3 ]
Gao, Rongmei [1 ,2 ]
He, Weiying [1 ,2 ]
You, Xuefu [1 ,2 ]
Li, Yuhuan [1 ,2 ]
Yu, Liyan [1 ,2 ]
Xiao, Chunling [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
[3] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[4] Jining Med Coll, Jining 272067, Shandong, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 09期
基金：
北京市自然科学基金;
关键词：
BIOSYNTHESIS; METABOLITES; POLIVIONE; ENTEROBACTERIACEAE; STREPTOTHRICINS; CITROMYCETIN; THEOBROXIDE; DERIVATIVES; FREQUENTANS; PRODUCTS;
D O I：
10.1021/np4000944
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three new polyketide compounds (1-3), a new quinolone alkaloid (4), and seven known polyketide derivatives were identified from the cultures of Penicillium sp. I09F 484, a strain isolated from the rhizosphere soil of the plant Picea asperata from Kanas Lake, Xinjiang, China. Their structures were elucidated by extensive spectroscopic data analysis. The absolute configurations of 1 and 4 were established by quantum chemical time-dependent density functional theory electronic circular dichroism calculation and Marfey's method, respectively. Compounds 1 and 2 displayed inhibitory activity against New Delhi metallo-beta-lactamase 1 with IC50 values of 94.9 and 87.9 mu M, respectively.
引用
收藏
页码：1535 / 1540
页数：6
相关论文
共 50 条
  • [1] New Delhi metallo-β-lactamase 1
    de Costa, Ayesha
    Mavalankar, Dileep
    LANCET INFECTIOUS DISEASES, 2010, 10 (11): : 752 - 752
  • [2] Inhibitory effect of soy saponins on the activity of β-lactamases, including New Delhi metallo-β-lactamase 1
    Horie, Hitoshi
    Chiba, Asuka
    Wada, Shigeo
    JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE, 2018, 55 (05): : 1948 - 1952
  • [3] Inhibitory effect of soy saponins on the activity of β-lactamases, including New Delhi metallo-β-lactamase 1
    Hitoshi Horie
    Asuka Chiba
    Shigeo Wada
    Journal of Food Science and Technology, 2018, 55 : 1948 - 1952
  • [4] New Delhi metallo-β-lactamase in Jamaica
    Thoms-Rodriguez, Camille-Ann
    Mazzulli, Tony
    Christian, Nicole
    Willey, Barbara M.
    Boyd, David A.
    Mataseje, Laura F.
    Mulvey, Michael R.
    Christie, Celia D. C.
    Nicholson, Alison M.
    JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 2016, 10 (02): : 183 - 187
  • [5] A practical electrochemical method for determining the inhibitory activity of New Delhi Metallo-β-lactamase-1 inhibitors
    Gan, Hongyu
    Liang, Yaowen
    Tang, Yun
    Huang, Manna
    Wan, Yiqian
    MICROCHEMICAL JOURNAL, 2023, 195
  • [6] Global spread of New Delhi metallo-β-lactamase 1
    Bogaerts, Pierre
    Verroken, Alexia
    Jans, Beatrice
    Denis, Olivier
    Glupczynski, Youri
    LANCET INFECTIOUS DISEASES, 2010, 10 (12): : 831 - 832
  • [7] New Delhi metallo-β-lactamase: a cautionary tale
    Muir, A.
    Weinbren, M. J.
    JOURNAL OF HOSPITAL INFECTION, 2010, 75 (03) : 239 - 240
  • [8] Emergence of New Delhi Metallo-β-Lactamase, Austria
    Zarfel, Gernot
    Hoenigl, Martin
    Leitner, Eva
    Salzer, Helmut J. F.
    Feierl, Gebhard
    Masoud, Lilian
    Valentin, Thomas
    Krause, Robert
    Grisold, Andrea J.
    EMERGING INFECTIOUS DISEASES, 2011, 17 (01) : 129 - 130
  • [9] New Delhi Metallo-β-Lactamase, Ontario, Canada
    Tijet, Nathalie
    Alexander, David C.
    Richardson, David
    Lastovetska, Olga
    Low, Donald E.
    Patel, Samir N.
    Melano, Roberto G.
    EMERGING INFECTIOUS DISEASES, 2011, 17 (02) : 306 - 307
  • [10] New Delhi metallo-β-lactamase-1: detection and prevention
    Walsh, Timothy R.
    CANADIAN MEDICAL ASSOCIATION JOURNAL, 2011, 183 (11) : 1240 - 1241
12345