Biocompatibility of Modified Bionanocellulose and Porous Poly(ε-caprolactone) Biomaterials

被引：9
|
作者：
Grobelski, Bartlomiej [1 ]
Wach, Radoslaw A. [2 ,3 ]
Adamus, Agnieszka [3 ]
Olejnik, Alicja K. [3 ]
Kowalska-Ludwicka, Karolina [2 ]
Kolodziejczyk, Marek [2 ]
Bielecki, Stanislaw [2 ]
Rosiak, Janusz M. [3 ]
Pasieka, Zbigniew [4 ]
机构：
[1] Lodz Univ Technol, Fac Pharm, PL-90924 Lodz, Poland
[2] Lodz Univ Technol, Inst Tech Biochem, PL-90924 Lodz, Poland
[3] Lodz Univ Technol, Inst Appl Radiat Chem, PL-90924 Lodz, Poland
[4] Med Univ Lodz, Dept Expt Surg, Lodz, Poland
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2014年 / 63卷 / 10期
关键词：
cytotoxicity; in vivo biocompatibility; bionanocellulose; tissue response; poly(epsilon-caprolactone); BACTERIAL CELLULOSE; MICROBIAL CELLULOSE; REGENERATION; TISSUE;
D O I：
10.1080/00914037.2013.854223
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Biocompatibility of modified bionanocellulose (BC) and porous poly(epsilon caprolactone) (PCL) were compared to UHMWPE. For all the materials lack of cytotoxic effect to mouse fibroblasts was observed in vitro. In vivo study, subcutaneous implantations in Wistar rats, lasted for seven, 14, and 30 days. Subsequently the composition of surrounding tissue and explants surface changes was evaluated. No symptoms of acute inflammation were observed. Surrounding tissue thickness, the number of granulocytes, lymphocytes, macrophages, and blood vessels differed in time and revealed regular healing process. It is concluded that investigated PCL and BC are the materials with superior biocompatibility with high application potential.
引用
收藏
页码：518 / 526
页数：9
相关论文
共 50 条
  • [21] In vivo biocompatibility of porous silicon biomaterials for drug delivery to the heart
    Tolli, Marja A.
    Ferreira, Monica P. A.
    Kinnunen, Sini M.
    Rysa, Jaana
    Makila, Ermei M.
    Szabo, Zoltan
    Serpi, Raisa E.
    Ohukainen, Pauli J.
    Valimaki, Mika J.
    Correia, Alexandra M. R.
    Salonen, Jarno J.
    Hirvonen, Jouni T.
    Ruskoaho, Heikki J.
    Santos, Helder A.
    BIOMATERIALS, 2014, 35 (29) : 8394 - 8405
  • [22] In vitro and in vivo ocular biocompatibility of electrospun poly(ε-caprolactone) nanofibers
    Da Silva, Gisele Rodrigues
    Lima, Tadeu Henrique
    Orefice, Rodrigo Lambert
    Fernandes-Cunha, Gabriella Maria
    Silva-Cunha, Armando
    Zhao, Min
    Behar-Cohen, Francine
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, 73 : 9 - 19
  • [23] Study on two kinds of degradation mechanisms for biomaterials poly(ε-caprolactone)
    陈建海
    陈一民
    陈志良
    Journal of Medical Colleges of PLA, 1999, (03) : 176 - 179
  • [24] BIOMATERIALS AND BIOCOMPATIBILITY
    WILLIAMS, DF
    MEDICAL PROGRESS THROUGH TECHNOLOGY, 1976, 4 (1-2) : 31 - 42
  • [25] Biomaterials and biocompatibility
    Pariente, JL
    Bordenave, L
    Conort, P
    PROGRES EN UROLOGIE, 2005, 15 (05): : 887 - 890
  • [26] Glycerol-modified poly(ε-caprolactone): an biocatalytic approach to improve the hydrophilicity of poly(ε-caprolactone)
    Soma Chakraborty
    James Nicolas M. Pagaduan
    Zara Kryzel A. Melgar
    Steffen Seitz
    Kai Kan
    Hiroharu Ajiro
    Polymer Bulletin, 2019, 76 : 1915 - 1928
  • [27] Glycerol-modified poly(ε-caprolactone): an biocatalytic approach to improve the hydrophilicity of poly(ε-caprolactone)
    Chakraborty, Soma
    Pagaduan, James Nicolas M.
    Melgar, Zara Kryzel A.
    Seitz, Steffen
    Kan, Kai
    Ajiro, Hiroharu
    POLYMER BULLETIN, 2019, 76 (04) : 1915 - 1928
  • [28] Phase behavior of blends of poly(ε-caprolactone) and a modified montmorillonite-poly(ε-caprolactone) nanocomposite
    Pucciariello, R
    Villani, V
    Gorrasi, G
    Vittoria, V
    JOURNAL OF MACROMOLECULAR SCIENCE-PHYSICS, 2005, B44 (01): : 79 - 92
  • [29] In vivo biocompatibility and biodegradability of poly(lactic acid)/poly(ε-caprolactone) blend compatibilized with poly(ε-caprolactone-b-tetrahydrofuran) in Wistar rats
    Conde, Gabriel
    de Carvalho, Julia Ribeiro Garcia
    Dias, Paula do Patrocinio
    Moranza, Henriette Gellert
    Montanhim, Gabriel Luiz
    Ribeiro, Juliana de Oliveira
    Chinelatto, Marcelo Aparecido
    Moraes, Paola Castro
    Taboga, Sebastiao Roberto
    Bertolo, Paulo Henrique Leal
    Goncalves Funnicelli, Michelli Inacio
    Pinheiro, Daniel Guariz
    Ferraz, Guilherme de Camargo
    BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, 2021, 7 (03):
  • [30] In vivo biocompatibility and biodegradation of 3D-printed porous scaffolds based on a hydroxyl-functionalized poly(ε-caprolactone)
    Seyednejad, Hajar
    Gawlitta, Debby
    Kuiper, Raoul V.
    de Bruin, Alain
    van Nostrum, Cornelus F.
    Vermonden, Tina
    Dhert, Wouter J. A.
    Hennink, Wim E.
    BIOMATERIALS, 2012, 33 (17) : 4309 - 4318
12345