Metal-free construction of aminated isoquinoline frameworks from 2-(2-oxo-2-arylethyl) benzonitrile in an aqueous medium

被引：3

作者：

Sharma, Himanshi ^{[1
]}

Kumar, Manoj ^{[1
]}

Sethi, Aaftaab ^{[1
,2
]}

Poonam, Brijesh ^{[3
]}

Rathi, Brijesh ^{[1
,2
]}

机构：

[1] Univ Delhi, Hansraj Coll, Dept Chem, Delhi 110007, India

[2] Univ Delhi, Hansraj Coll, HeteroChem InnoTech, Delhi 110007, India

[3] Univ Delhi, Dept Chem, Miranda House, Delhi 110007, India

来源：

GREEN CHEMISTRY | 2023年 / 25卷 / 01期

关键词：

LONG-LIVED CATALYSTS; ARYLBORONIC ACIDS; IRIDIUM COMPLEXES; ARYL CHLORIDES; NITRILES; AMINES; 1-AMINOISOQUINOLINES; ACTIVATION; HETEROARYL; ADDITIONS;

D O I：

10.1039/d2gc04044a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we report a metal-free protocol for the activation of nitrile towards the nucleophilic addition and subsequent annulation under an aqueous medium for the first time. The protocol divulges an efficient route for the construction of diversified aminated isoquinolines. Differently substituted primary as well as secondary amines underwent the reaction in a highly regioselective manner. The reaction is operationally simple, shows high functional group tolerance, easier modification of well-known drugs, and successfully extended to gram-scale synthesis.

引用

页码：167 / 171

页数：5

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