A Convenient Synthesis of Tri- and Tetramethylbenzaldehydes from Readily Available Phenols

被引：4

作者：

Dhankher, Persis ^{[1
]}

Sheppard, Tom D. ^{[1
]}

机构：

[1] UCL, Dept Chem, London WC1H 0AJ, England

来源：

SYNLETT | 2014年 / 25卷 / 03期

关键词：

aldehydes; palladium; Suzuki; aromatic compounds; formylation; ACID; ISOMERIZATION; DERIVATIVES; REACTIVITY; NITRATION; ALDEHYDES; RING;

D O I：

10.1055/s-0033-1340302

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This letter describes a convenient synthesis of the six isomeric tri- and tetramethylbenzaldehydes, which are not readily available from major chemical suppliers. Formylation of readily available phenols via electrophilic aromatic substitution provides compounds containing the correct aromatic substitution pattern. Suzuki cross-coupling of the corresponding trifluoromethanesulfonates with methylboronic acid then provides the benzaldehydes as single isomers.

引用

页码：381 / 384

页数：4

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